Arteriolar vasoconstrictive response: comparing the effects of arginine vasopressin and norepinephrine


Autoria(s): Friesenecker, Barbara E; Tsai, Amy G; Martini, Judith; Ulmer, Hanno; Wenzel, Volker; Hasibeder, Walter R; Intaglietta, Marcos; Dünser, Martin W
Data(s)

2006

Resumo

INTRODUCTION: This study was designed to examine differences in the arteriolar vasoconstrictive response between arginine vasopressin (AVP) and norepinephrine (NE) on the microcirculatory level in the hamster window chamber model in unanesthetized, normotonic hamsters using intravital microscopy. It is known from patients with advanced vasodilatory shock that AVP exerts strong additional vasoconstriction when incremental dosage increases of NE have no further effect on mean arterial blood pressure (MAP). METHODS: In a prospective controlled experimental study, eleven awake, male golden Syrian hamsters were instrumented with a viewing window inserted into the dorsal skinfold. NE (2 microg/kg/minute) and AVP (0.0001 IU/kg/minute, equivalent to 4 IU/h in a 70 kg patient) were continuously infused to achieve a similar increase in MAP. According to their position within the arteriolar network, arterioles were grouped into five types: A0 (branch off small artery) to A4 (branch off A3 arteriole). RESULTS: Reduction of arteriolar diameter (NE, -31 +/- 12% versus AVP, -49 +/- 7%; p = 0.002), cross sectional area (NE, -49 +/- 17% versus AVP, -73 +/- 7%; p = 0.002), and arteriolar blood flow (NE, -62 +/- 13% versus AVP, -80 +/- 6%; p = 0.004) in A0 arterioles was significantly more pronounced in AVP animals. There was no difference in red blood cell velocities in A0 arterioles between groups. The reduction of diameter, cross sectional area, red blood cell velocity, and arteriolar blood flow in A1 to A4 arterioles was comparable in AVP and NE animals. CONCLUSION: Within the microvascular network, AVP exerted significantly stronger vasoconstriction on large A0 arterioles than NE under physiological conditions. This observation may partly explain why AVP is such a potent vasopressor hormone and can increase systemic vascular resistance even in advanced vasodilatory shock unresponsive to increases in standard catecholamine therapy.

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application/pdf

Identificador

http://boris.unibe.ch/20405/1/1.pdf

Friesenecker, Barbara E; Tsai, Amy G; Martini, Judith; Ulmer, Hanno; Wenzel, Volker; Hasibeder, Walter R; Intaglietta, Marcos; Dünser, Martin W (2006). Arteriolar vasoconstrictive response: comparing the effects of arginine vasopressin and norepinephrine. Critical care, 10(3), R75. London: BioMed Central 10.1186/cc4922 <http://dx.doi.org/10.1186/cc4922>

doi:10.7892/boris.20405

info:doi:10.1186/cc4922

info:pmid:16696866

urn:issn:1364-8535

urn:isbn:16696866

Idioma(s)

eng

Publicador

BioMed Central

Relação

http://boris.unibe.ch/20405/

Direitos

info:eu-repo/semantics/openAccess

Fonte

Friesenecker, Barbara E; Tsai, Amy G; Martini, Judith; Ulmer, Hanno; Wenzel, Volker; Hasibeder, Walter R; Intaglietta, Marcos; Dünser, Martin W (2006). Arteriolar vasoconstrictive response: comparing the effects of arginine vasopressin and norepinephrine. Critical care, 10(3), R75. London: BioMed Central 10.1186/cc4922 <http://dx.doi.org/10.1186/cc4922>

Tipo

info:eu-repo/semantics/article

info:eu-repo/semantics/publishedVersion

PeerReviewed