Sugar modification as a means to increase the biological performance of oligonucleotides
| Data(s) |
01/11/2006
|
|---|---|
| Resumo |
Modification of the ribose unit in DNA and RNA profoundly influences the self-rcognition and the biological properties of the nucleic acids. Conformational restriction of the ribose units, as in LNA and tricyclo-DNA, has been identified as a powerful tool to increase DNA and RNA affinity as well as biological stability and antisense properties. Apart from that sugar modified DNA analogues, as homo-DNA, have shown to be orthogonal base-pairing systems which by virtue of non-crosscommunicating with the natural nucleic acids open novel applications in biotechnology. |
| Formato |
application/pdf |
| Identificador |
http://boris.unibe.ch/18318/1/55.pdf Leumann, Christian (2006). Sugar modification as a means to increase the biological performance of oligonucleotides. Nucleic Acids Symposium Series, 50(1), pp. 55-56. Oxford University Press 10.1093/nass/nrl167 <http://dx.doi.org/10.1093/nass/nrl167> doi:10.7892/boris.18318 info:doi:10.1093/nass/nrl167 urn:issn:0261-3166 |
| Idioma(s) |
eng |
| Publicador |
Oxford University Press |
| Relação |
http://boris.unibe.ch/18318/ |
| Direitos |
info:eu-repo/semantics/restrictedAccess |
| Fonte |
Leumann, Christian (2006). Sugar modification as a means to increase the biological performance of oligonucleotides. Nucleic Acids Symposium Series, 50(1), pp. 55-56. Oxford University Press 10.1093/nass/nrl167 <http://dx.doi.org/10.1093/nass/nrl167> |
| Tipo |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion NonPeerReviewed |
