Targeting the insulin-like growth factor-1 receptor in human cancer


Autoria(s): Arcaro, Alexandre
Data(s)

2013

Resumo

The insulin-like growth factor (IGF) signaling system plays a crucial role in human cancer and the IGF-1 receptor (IGF-1R) is an attractive drug target against which a variety of novel anti-tumor agents are being developed. Deregulation of the IGF signaling pathway frequently occurs in human cancer and involves the establishment of autocrine loops comprising IGF-1 or IGF-2 and/or IGF-1R over-expression. Epidemiologic studies have documented a link between elevated IGF levels and the development of solid tumors, such as breast, colon, and prostate cancer. Anti-cancer strategies targeting the IGF signaling system involve two main approaches, namely neutralizing antibodies and small molecule inhibitors of the IGF-1R kinase activity. There are numerous reports describing anti-tumor activity of these agents in pre-clinical models of major human cancers. In addition, multiple clinical trials have started to evaluate the safety and efficacy of selected IGF-1R inhibitors, in combination with standard chemotherapeutic regimens or other targeted agents in cancer patients. In this mini review, I will discuss the role of the IGF signaling system in human cancer and the main strategies which have been so far evaluated to target the IGF-1R.

Formato

application/pdf

Identificador

http://boris.unibe.ch/16508/1/fphar-04-00030.pdf

Arcaro, Alexandre (2013). Targeting the insulin-like growth factor-1 receptor in human cancer. Frontiers in Pharmacology, 4, p. 30. Frontiers 10.3389/fphar.2013.00030 <http://dx.doi.org/10.3389/fphar.2013.00030>

doi:10.7892/boris.16508

info:doi:10.3389/fphar.2013.00030

info:pmid:23525758

urn:issn:1663-9812

Idioma(s)

eng

Publicador

Frontiers

Relação

http://boris.unibe.ch/16508/

Direitos

info:eu-repo/semantics/openAccess

Fonte

Arcaro, Alexandre (2013). Targeting the insulin-like growth factor-1 receptor in human cancer. Frontiers in Pharmacology, 4, p. 30. Frontiers 10.3389/fphar.2013.00030 <http://dx.doi.org/10.3389/fphar.2013.00030>

Palavras-Chave #610 Medicine & health
Tipo

info:eu-repo/semantics/article

info:eu-repo/semantics/publishedVersion

PeerReviewed