The Impact of PPARγ Genetic Variants on IBD Susceptibility and IBD Disease Course


Autoria(s): Mwinyi, Jessica; Grete-Wenger, Christa; Eloranta, Jyrki J.; Kullak-Ublick, Gerd A.
Data(s)

2012

Resumo

PPARγ is a nuclear receptor that regulates numerous pathways including cytokine expression and immune responses and plays an important role in controlling colon inflammation. We aimed at determining the occurring PPARγ SNPs, at predicting the haplotypes, and at determining the frequency outcome in inflammatory bowel disease (IBD) patients in comparison with healthy controls. We determined genetic variants in the coding exons and flanking intronic sequences of the NR1C3 gene in 284 IBD patients and 194 controls and predicted NR1C3 haplotypes via bioinformatic analysis. We investigated whether certain NR1C3 variants are associated with susceptibility to IBD or its disease course. None of the detected 22 NR1C3 variants were associated with IBD. Two variants with allelic frequencies over 1% were included in haplotype/diplotype analyses. None of the NR3C1 haplotypes showed association with IBD development or disease course. We conclude that NR1C3 haplotypes are not related to IBD susceptibility or IBD disease activity.

Formato

application/pdf

Identificador

http://boris.unibe.ch/16181/1/349469.pdf

Mwinyi, Jessica; Grete-Wenger, Christa; Eloranta, Jyrki J.; Kullak-Ublick, Gerd A. (2012). The Impact of PPARγ Genetic Variants on IBD Susceptibility and IBD Disease Course. PPAR Research, 2012, p. 349469. New York, N.Y.: Hindawi Publishing Corporation 10.1155/2012/349469 <http://dx.doi.org/10.1155/2012/349469>

doi:10.7892/boris.16181

info:doi:10.1155/2012/349469

info:pmid:22448164

urn:issn:1687-4757

Idioma(s)

eng

Publicador

Hindawi Publishing Corporation

Relação

http://boris.unibe.ch/16181/

Direitos

info:eu-repo/semantics/openAccess

Fonte

Mwinyi, Jessica; Grete-Wenger, Christa; Eloranta, Jyrki J.; Kullak-Ublick, Gerd A. (2012). The Impact of PPARγ Genetic Variants on IBD Susceptibility and IBD Disease Course. PPAR Research, 2012, p. 349469. New York, N.Y.: Hindawi Publishing Corporation 10.1155/2012/349469 <http://dx.doi.org/10.1155/2012/349469>

Tipo

info:eu-repo/semantics/article

info:eu-repo/semantics/publishedVersion

PeerReviewed