Cooperative and Noncooperative Assembly of Oligopyrenotides Resolved by Atomic Force Microscopy
Data(s) |
2012
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Resumo |
The supramolecular assembly of amphiphilic oligopyrenotide building blocks (covalently linked heptapyrene, Py7) is studied by atomic force microscopy (AFM) in combination with optical spectroscopy. The assembly process is triggered in a controlled manner by increasing the ionic strength of the aqueous oligomer solution. Cooperative noncovalent interactions between individual oligomeric units lead to the formation of DNA-like supramolecular polymers. We also show that the terminal attachment of a single cytidine nucleotide to the heptapyrenotide (Py7-C) changes the association process from a cooperative (nucleation−elongation) to a noncooperative (isodesmic) regime, suggesting a structure misfit between the cytidine and the pyrene units. We also demonstrate that AFM enables the identification and characterization of minute concentrations of the supramolecular products, which was not accessible by conventional optical spectroscopy. |
Formato |
application/pdf |
Identificador |
http://boris.unibe.ch/15278/1/ma3007619.pdf Rudnev, Alexander; Malinovskii, Vladimir L.; Nussbaumer, Alina Laura; Mishchenko, Artem; Häner, Robert; Wandlowski, Thomas (2012). Cooperative and Noncooperative Assembly of Oligopyrenotides Resolved by Atomic Force Microscopy. Macromolecules, 45(15), pp. 5986-5992. Washington, D.C.: American Chemical Society 10.1021/ma3007619 <http://dx.doi.org/10.1021/ma3007619> doi:10.7892/boris.15278 info:doi:10.1021/ma3007619 urn:issn:0024-9297 |
Idioma(s) |
eng |
Publicador |
American Chemical Society |
Relação |
http://boris.unibe.ch/15278/ |
Direitos |
info:eu-repo/semantics/restrictedAccess |
Fonte |
Rudnev, Alexander; Malinovskii, Vladimir L.; Nussbaumer, Alina Laura; Mishchenko, Artem; Häner, Robert; Wandlowski, Thomas (2012). Cooperative and Noncooperative Assembly of Oligopyrenotides Resolved by Atomic Force Microscopy. Macromolecules, 45(15), pp. 5986-5992. Washington, D.C.: American Chemical Society 10.1021/ma3007619 <http://dx.doi.org/10.1021/ma3007619> |
Palavras-Chave | #570 Life sciences; biology #540 Chemistry |
Tipo |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion PeerReviewed |