Synthesis, binding and cellular uptake properties of oligodeoxynucleotides containing cationic bicyclo-thymidine residues
| Data(s) |
2011
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|---|---|
| Resumo |
The synthesis and incorporation into oligodeoxynucleotides of two novel derivatives of bicyclothymidine carrying a cationic diaminopropyl or lysine unit in the C(6′)-β position is described. Compared to unmodified DNA these oligonucleotides show Tm-neutral behavior when paired against complementary DNA and are destabilizing when paired against RNA. Unaided uptake experiments of a decamer containing five lys-bcT units into HeLa and HEK293T cells showed substantial internalization with mostly cytosolic distribution which was not observed in the case of an unmodified control oligonucleotide. |
| Formato |
application/pdf |
| Identificador |
http://boris.unibe.ch/9416/1/Jory_2011.pdf Lietard, Jory; Ittig, Damian; Leumann, Christian J. (2011). Synthesis, binding and cellular uptake properties of oligodeoxynucleotides containing cationic bicyclo-thymidine residues. Bioorganic & medicinal chemistry, 19(19), pp. 5869-5875. Amsterdam: Elsevier 10.1016/j.bmc.2011.08.022 <http://dx.doi.org/10.1016/j.bmc.2011.08.022> doi:10.7892/boris.9416 info:doi:10.1016/j.bmc.2011.08.022 urn:issn:0968-0896 |
| Idioma(s) |
eng |
| Publicador |
Elsevier |
| Relação |
http://boris.unibe.ch/9416/ |
| Direitos |
info:eu-repo/semantics/restrictedAccess |
| Fonte |
Lietard, Jory; Ittig, Damian; Leumann, Christian J. (2011). Synthesis, binding and cellular uptake properties of oligodeoxynucleotides containing cationic bicyclo-thymidine residues. Bioorganic & medicinal chemistry, 19(19), pp. 5869-5875. Amsterdam: Elsevier 10.1016/j.bmc.2011.08.022 <http://dx.doi.org/10.1016/j.bmc.2011.08.022> |
| Palavras-Chave | #570 Life sciences; biology #540 Chemistry |
| Tipo |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion PeerReviewed |
