Bioengineered periodontal tissue formed on titanium dental implants


Autoria(s): Lin, Yan; Gallucci, German O; Buser, Daniel; Bosshardt, Dieter; Belser, Urs; Yelick, Pamela C
Data(s)

2011

Resumo

The ability to use autologous dental progenitor cells (DPCs) to form organized periodontal tissues on titanium implants would be a significant improvement over current implant therapies. Based on prior experimental results, we hypothesized that rat periodontal ligament (PDL)-derived DPCs can be used to bioengineer PDL tissues on titanium implants in a novel, in vivo rat maxillary molar implant model. Analyses of recovered implants revealed organized PDL tissues surrounding titanium implant surfaces in PDL-cell-seeded, and not in unseeded control, implants. Rat PDL DPCs also exhibited differentiative potential characteristic of stem cells. These proof-of-principle findings suggest that PDL DPCs can organize periodontal tissues in the jaw, at the site of previously lost teeth, indicating that this method holds potential as an alternative approach to osseointegrated dental implants. Further refinement of this approach will facilitate the development of clinically relevant methods for autologous PDL regeneration on titanium implants in humans.

Formato

application/pdf

Identificador

http://boris.unibe.ch/4467/1/J%20DENT%20RES-2011-Lin-251-6.pdf

Lin, Yan; Gallucci, German O; Buser, Daniel; Bosshardt, Dieter; Belser, Urs; Yelick, Pamela C (2011). Bioengineered periodontal tissue formed on titanium dental implants. Journal of dental research, 90(2), pp. 251-6. Thousand Oaks, Calif.: Sage 10.1177/0022034510384872 <http://dx.doi.org/10.1177/0022034510384872>

doi:10.7892/boris.4467

info:doi:10.1177/0022034510384872

info:pmid:21149858

urn:issn:0022-0345

Idioma(s)

eng

Publicador

Sage

Relação

http://boris.unibe.ch/4467/

Direitos

info:eu-repo/semantics/restrictedAccess

Fonte

Lin, Yan; Gallucci, German O; Buser, Daniel; Bosshardt, Dieter; Belser, Urs; Yelick, Pamela C (2011). Bioengineered periodontal tissue formed on titanium dental implants. Journal of dental research, 90(2), pp. 251-6. Thousand Oaks, Calif.: Sage 10.1177/0022034510384872 <http://dx.doi.org/10.1177/0022034510384872>

Palavras-Chave #610 Medicine & health
Tipo

info:eu-repo/semantics/article

info:eu-repo/semantics/publishedVersion

PeerReviewed