Tetracycline regulator expression alters the transcriptional program of mammalian cells


Autoria(s): Hackl, Hubert; Rommer, Anna; Konrad, Torsten A; Nassimbeni, Christine; Wieser, Rotraud
Data(s)

2010

Resumo

Tetracycline regulated ectopic gene expression is a widely used tool to study gene function. However, the tetracycline regulator (tetR) itself has been reported to cause certain phenotypic changes in mammalian cells. We, therefore, asked whether human myeloid U937 cells expressing the tetR in an autoregulated manner would exhibit alterations in gene expression upon removal of tetracycline.

Formato

application/pdf

Identificador

http://boris.unibe.ch/3368/1/journal.pone.0013013.pdf

Hackl, Hubert; Rommer, Anna; Konrad, Torsten A; Nassimbeni, Christine; Wieser, Rotraud (2010). Tetracycline regulator expression alters the transcriptional program of mammalian cells. PLoS ONE, 5(9), e13013. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0013013 <http://dx.doi.org/10.1371/journal.pone.0013013>

doi:10.7892/boris.3368

info:doi:10.1371/journal.pone.0013013

info:pmid:20886048

urn:issn:1932-6203

Idioma(s)

eng

Publicador

Public Library of Science

Relação

http://boris.unibe.ch/3368/

Direitos

info:eu-repo/semantics/openAccess

Fonte

Hackl, Hubert; Rommer, Anna; Konrad, Torsten A; Nassimbeni, Christine; Wieser, Rotraud (2010). Tetracycline regulator expression alters the transcriptional program of mammalian cells. PLoS ONE, 5(9), e13013. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0013013 <http://dx.doi.org/10.1371/journal.pone.0013013>

Tipo

info:eu-repo/semantics/article

info:eu-repo/semantics/publishedVersion

NonPeerReviewed