The protease inhibitor alpha-2-macroglobulin-like-1 is the p170 antigen recognized by paraneoplastic pemphigus autoantibodies in human


Autoria(s): Schepens, Isabelle; Jaunin, Fabienne; Begre, Nadja; Läderach, Ursula; Marcus, Katrin; Hashimoto, Takashi; Favre, Bertrand; Borradori, Luca
Data(s)

2010

Resumo

Paraneoplastic pemphigus (PNP) is a devastating autoimmune blistering disease, involving mucocutaneous and internal organs, and associated with underlying neoplasms. PNP is characterized by the production of autoantibodies targeting proteins of the plakin and cadherin families involved in maintenance of cell architecture and tissue cohesion. Nevertheless, the identity of an antigen of Mr 170,000 (p170), thought to be critical in PNP pathogenesis, has remained unknown.

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http://boris.unibe.ch/2261/1/fetchObject.pdf

Schepens, Isabelle; Jaunin, Fabienne; Begre, Nadja; Läderach, Ursula; Marcus, Katrin; Hashimoto, Takashi; Favre, Bertrand; Borradori, Luca (2010). The protease inhibitor alpha-2-macroglobulin-like-1 is the p170 antigen recognized by paraneoplastic pemphigus autoantibodies in human. PLoS ONE, 5(8), e12250. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0012250 <http://dx.doi.org/10.1371/journal.pone.0012250>

doi:10.7892/boris.2261

info:doi:10.1371/journal.pone.0012250

info:pmid:20805888

urn:issn:1932-6203

Idioma(s)

eng

Publicador

Public Library of Science

Relação

http://boris.unibe.ch/2261/

Direitos

info:eu-repo/semantics/openAccess

Fonte

Schepens, Isabelle; Jaunin, Fabienne; Begre, Nadja; Läderach, Ursula; Marcus, Katrin; Hashimoto, Takashi; Favre, Bertrand; Borradori, Luca (2010). The protease inhibitor alpha-2-macroglobulin-like-1 is the p170 antigen recognized by paraneoplastic pemphigus autoantibodies in human. PLoS ONE, 5(8), e12250. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0012250 <http://dx.doi.org/10.1371/journal.pone.0012250>

Palavras-Chave #610 Medicine & health
Tipo

info:eu-repo/semantics/article

info:eu-repo/semantics/publishedVersion

PeerReviewed