Charakterisierung verschiedener Reifungsstadien humaner dendritischer Zellen und ihr Einfluss auf die T-Zelldifferenzierung

Diese Zusammenfassung der kumulativen Habilitationsschrift bezieht sich auf folgende Originalarbeiten:

1. Jonuleit, H., U. Kühn, G. Müller, K. Steinbrink, L. Paragnik, E. Schmitt, J. Knop, and A.H. Enk 1997. Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditions. Eur J Immunol 27:3135.2. Jonuleit, H., A. Giesecke, A. Kandemir, L. Paragnik, J. Knop, and A.H. Enk 2000. Induction of tumor peptide-specific cytotoxic T cells under serum-free conditions by mature human dendritic cells. Arch Dermatol Res 292:325.3. Jonuleit, H., A. Giesecke-Tüttenberg, T. Tüting, B. Thurner-Schuler, L. Paragnik, A. Kandemir, G. Schuler J. Knop and A.H. Enk 2001. A comparison of two types of dendritic cell as adjuvants for the induction of melanoma-specific T cell responses in humans following intranodal injection. Int J Cancer 93:243.4. Jonuleit, H., E. Schmitt, G. Schuler, J. Knop, and A.H. Enk 2000. Induction of Interleukin 10-producing, Nonproliferating CD4+ T Cells with Regulatory Properties by Repetitive Stimulation with Allogeneic Immature Human Dendritic Cells. J Exp Med (192) 9:1213.5. Jonuleit, H., E. Schmitt, M. Stassen, A. Tüttenberg, J. Knop and A.H. Enk 2001. Identification and functional characterization of human CD4+CD25+ T cells with regulatory properties isolated from peripheral blood. J Exp Med (193) 11:1285.