Adverse events related to vancomycin use in a University Hospital in Brazil
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
15/09/2014
15/09/2014
2013
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Resumo |
Introduction and Objectives: Vancomycin is indicated to patients who have not responded to treatment with other antibiotics in serious infections caused by organisms susceptible to it and resistant to other antimicrobials. However, over the last five years, many adverse reactions have been reported with this medicine in the University Hospital of the University of Silo Paulo (HU/USP), such as nephrotoxicity and toxicity related to infusion. Some critical patients, for example surgical patients with sepsis and severe trauma are generally susceptible to renal failure due to the severity of the underlying disease. The-aim of this study is to quantify and delineate the epidemiological profile of confirmed adverse reactions caused by vancomycin. Material and Methods: We conducted a retrospective observational quantitative study of medical records of patients who had confirmed.adverse reactions occurred with vancomycin in the period from January 2007 to May 2012, at the HU/USP - Brazil. All notifications related to vancomycin were evaluated in the following items: age and sex of patients, type and ward where the adverse event occurred involving this drug. Results and Conclusions: During the analysed period, were confinued 37 adverse events with vancomycn. The adults represented 75,7% of the cases, and the children 24,3%. The present study shows that adult patients admitted to the medical clinic had greater susceptibility to adverse reactions to vancomycin and for pediatric patients its higher frequency was at ICU. Despite the adverse skin reactions performed with greater frequency, it is known that the most severe reactions were related to the kidney resulting in more complex clinical interventions. Apresentado no XVIII Pharmaceutical Science and Technology Meeting of the Faculty of Pharmaceutical Sciences; III Symposium on drug design and development for Neglected Diseases; V Workshop on Melanoma, skin and photoprotection - Faculty of Pharmaceutical Sciences University of São Paulo - October 21-25, 2013 - São Paulo - Brazil |
Identificador |
Brazilian Journal of Pharmaceutical Sciences, São Paulo, v. 49, suppl. 1, p. 17, 2013. |
Idioma(s) |
eng |
Publicador |
São Paulo |
Relação |
Brazilian Journal of Pharmaceutical Sciences |
Direitos |
openAccess |
Palavras-Chave | #ANTIBIÓTICOS (EFEITOS ADVERSOS) #HOSPITAIS UNIVERSITÁRIOS |
Tipo |
article abstracts publishedVersion |