Adaptive immunity is related to coronary artery disease severity after acute coronary syndrome in subjects with metabolic syndrome


Autoria(s): Izar, Maria Cristina de Oliveira; Fonseca, Henrique A.; Pinheiro, Luiz F.; Monteiro, Carlos M.; Póvoa, Rui M.; Monteiro, Andrea Moreira; Figueiredo Neto, Antonio Martins; Gidlund, Magnus Ake; Fonseca, Francisco A.
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

28/03/2014

28/03/2014

01/01/2013

Resumo

Metabolic syndrome (MetS) is an inflammatory state associated with high coronary disease risk. Inflammation and adaptive immunity modulate atherosclerosis and plaque instability. We examined early changes in anti-oxidized lowdensity lipoprotein (LDL) (anti-oxLDL) autoantibodies (Abs) in patients with MetS after an acute coronary syndrome (ACS). Patients of both genders (n=116) with MetS were prospectively included after an acute yocardial infarction (MI) or hospitalization due to unstable angina. Anti-oxLDL Abs (IgG class) were assayed at baseline, three and six weeks after ACS. The severity of coronary disease was evaluated by the Gensini score. We observed a decrease in anti-oxLDL Abs titers (p<0.002 vs. baseline), mainly in males (p=0.01), in those under 65 y (p=0.03), and in subjects with Gensini score above median (p=0.04). In conclusion, early decrease in circulating anti-oxLDL Abs is associated with coronary disease severity among subjects with MetS.

FAPESP - 2004/00325-8

CNPq-INCT-FCx

INCT-INAMI

Identificador

Diabetes and Vascular Disease Research, Londres, v.10, n.1, p.32-39, 2013

http://www.producao.usp.br/handle/BDPI/44305

10.1177/1479164112443374

http://dx.doi.org/10.1177/1479164112443374

Idioma(s)

eng

Publicador

Sherborne Gibbs

Londres

Relação

Diabetes and Vascular Disease Research

Direitos

restrictedAccess

The author(s)

Palavras-Chave #Acute coronary syndrome (ACS) #Autoantibodies (Abs) #Metabolic syndrome (MetS) #Oxidized low-density lipoprotein (oxLDL) #Síndrome coronariana aguda #Sistema imune #Artérias #Auto-anticorpos
Tipo

article

original article

publishedVersion