Adaptive immunity is related to coronary artery disease severity after acute coronary syndrome in subjects with metabolic syndrome
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
28/03/2014
28/03/2014
01/01/2013
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Resumo |
Metabolic syndrome (MetS) is an inflammatory state associated with high coronary disease risk. Inflammation and adaptive immunity modulate atherosclerosis and plaque instability. We examined early changes in anti-oxidized lowdensity lipoprotein (LDL) (anti-oxLDL) autoantibodies (Abs) in patients with MetS after an acute coronary syndrome (ACS). Patients of both genders (n=116) with MetS were prospectively included after an acute yocardial infarction (MI) or hospitalization due to unstable angina. Anti-oxLDL Abs (IgG class) were assayed at baseline, three and six weeks after ACS. The severity of coronary disease was evaluated by the Gensini score. We observed a decrease in anti-oxLDL Abs titers (p<0.002 vs. baseline), mainly in males (p=0.01), in those under 65 y (p=0.03), and in subjects with Gensini score above median (p=0.04). In conclusion, early decrease in circulating anti-oxLDL Abs is associated with coronary disease severity among subjects with MetS. FAPESP - 2004/00325-8 CNPq-INCT-FCx INCT-INAMI |
Identificador |
Diabetes and Vascular Disease Research, Londres, v.10, n.1, p.32-39, 2013 http://www.producao.usp.br/handle/BDPI/44305 10.1177/1479164112443374 |
Idioma(s) |
eng |
Publicador |
Sherborne Gibbs Londres |
Relação |
Diabetes and Vascular Disease Research |
Direitos |
restrictedAccess The author(s) |
Palavras-Chave | #Acute coronary syndrome (ACS) #Autoantibodies (Abs) #Metabolic syndrome (MetS) #Oxidized low-density lipoprotein (oxLDL) #Síndrome coronariana aguda #Sistema imune #Artérias #Auto-anticorpos |
Tipo |
article original article publishedVersion |