Modulation of host cell signaling pathways as a therapeutic approach in periodontal disease


Autoria(s): Souza, João Antonio Chaves de; Rossa Junior, Carlos; Garlet, Gustavo Pompermaier; Nogueira, Andressa Vilas Boas; Cirelli, Joni Augusto
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

04/11/2013

04/11/2013

2012

Resumo

Recently, new treatment approaches have been developed to target the host component of periodontal disease. This review aims at providing updated information on host-modulating therapies, focusing on treatment strategies for inhibiting signal transduction pathways involved in inflammation. Pharmacological inhibitors of MAPK, NFκB and JAK/STAT pathways are being developed to manage rheumatoid arthritis, periodontal disease and other inflammatory diseases. Through these agents, inflammatory mediators can be inhibited at cell signaling level, interfering on transcription factors activation and inflammatory gene expression. Although these drugs offer great potential to modulate host response, their main limitations are lack of specificity and developments of side effects. After overcoming these limitations, adjunctive host modulating drugs will provide new therapeutic strategies for periodontal treatment.

Identificador

J. Appl. Oral Sci.,v.20,n.2,p.128-138,2012

1678-7757

http://www.producao.usp.br/handle/BDPI/40153

10.1590/S1678-77572012000200002

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572012000200002&lng=en&nrm=iso&tlng=en

http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1678-77572012000200002&lng=en&nrm=iso&tlng=en

http://www.scielo.br/scielo.php?script=sci_pdf&pid=S1678-77572012000200002&lng=en&nrm=iso&tlng=en

Idioma(s)

eng

Publicador

Faculdade De Odontologia De Bauru - USP

Relação

Journal of Applied Oral Science

Direitos

openAccess

Palavras-Chave #Periodontitis #Signal transduction #Janus kinases #STAT transcription factors #Mitogen-activated protein kinases #NF-kappa B
Tipo

article

original article