Different levels of MT-I/II between patients with MTLE with or without seizure generalization: does hippocampal MT-I/II affects seizure spread, or does seizure spread promotes differential expression of MT-I/II?


Autoria(s): Peixoto-Santos, José Eduardo; Galvis-Alonso, Orfa Yineth; Velasco, Tonicarlo R.; Kandratavicius, Ludmyla; Assirati Jr, João Alberto; Carlotti, Carlos Gilberto; Scandiuzzi, Renata Caldo; Serafini, Luciano Neder; Leite, João Pereira
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

04/11/2013

04/11/2013

2012

Resumo

In the central nervous system, zinc is released along with glutamate during neurotransmission and, in excess, can promote neuronal death. Experimental studies have shown that metallothioneins I/II (MT-I/II), which chelate free zinc, can affect seizures and reduce neuronal death after status epilepticus. Our aim was to evaluate the expression of MT-I/II in the hippocampus of patients with temporal lobe epilepsy (TLE). Hippocampi from patients with pharmacoresistant mesial temporal lobe epilepsy (MTLE) were evaluated for expression of MT-I/II and for neuronal, astroglial, and microglial populations. Compared to control cases, MTLE group displayed widespread increase in MT-I/II expression, astrogliosis and reduced neuronal population. MT-I/II levels did not correlate with any clinical variables, but patients with secondary generalized seizures (SGS) had less MT-I/II than patients without SGS. In conclusion, MT-I/II expression was increased in hippocampi from MTLE patients and our data suggest that it may be associated with different seizure spread patterns.

Identificador

J. epilepsy clin. neurophysiol.,v.18,n.1,p.16-20,2012

1676-2649

http://www.producao.usp.br/handle/BDPI/40112

10.1590/S1676-26492012000100005

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-26492012000100005&lng=en&nrm=iso&tlng=en

http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1676-26492012000100005&lng=en&nrm=iso&tlng=en

http://www.scielo.br/scielo.php?script=sci_pdf&pid=S1676-26492012000100005&lng=en&nrm=iso&tlng=en

Idioma(s)

eng

Publicador

Liga Brasileira de Epilepsia (LBE)

Relação

Journal of Epilepsy and Clinical Neurophysiology

Direitos

openAccess

Palavras-Chave #Metallothioneins #zinc homeostasis #gliosis #epilepsy #neuronal density #Metalotioneínas #homeostase do zinco #gliose #epilepsia #densidade neuronal
Tipo

article

original article