Cyclic voltammetry and computational chemistry studies on the evaluation of the redox behavior of parabens and other analogues


Autoria(s): Gil, Eric de S.; Andrade, Carolina H.; Barbosa, Núsia L.; Braga, Rodolpho C.; Serrano, Sílvia H. P.
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

04/11/2013

04/11/2013

2012

Resumo

Parabens are antimicrobial preservatives widely used in pharmaceutical, cosmetic and food industries. The alkyl chain connected to the ester group defines some important physicochemical characteristics of these compounds, including the partition coefficient and redox properties. The voltammetric and computational analyses were carried out in order to evaluate the redox behavior of these compounds and other phenolic analogues. A strong correlation between chemical substituents inductive effects of parabens with redox potentials was observed. Using cyclic voltammetry and glassy carbon working electrode, only one irreversible anodic peak was observed around 0.8 V for methylparaben (MP), ethylparaben (EP), propylparaben (PP), butylparaben (BP), benzylparaben (BzP) and p-substituted phenolic analogues. The electrodonating inductive effect of alkyl groups was demonstrated by the anodic oxidation potential shift to lower values as the carbon number increases and, therefore the parabens (and other phenolic analogues) oxidation processes to the quinonoidic forms showed great dependence on the substituent pattern.

Identificador

J. Braz. Chem. Soc.,v.23,n.3,p.565-572,2012

0103-5053

http://www.producao.usp.br/handle/BDPI/39221

10.1590/S0103-50532012000300025

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532012000300025&lng=en&nrm=iso&tlng=en

http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0103-50532012000300025&lng=en&nrm=iso&tlng=en

http://www.scielo.br/scielo.php?script=sci_pdf&pid=S0103-50532012000300025&lng=en&nrm=iso&tlng=en

Idioma(s)

eng

Publicador

Sociedade Brasileira de Química

Relação

Journal of the Brazilian Chemical Society

Direitos

openAccess

Palavras-Chave #preservatives #electroanalysis #computational chemistry #substituent pattern #phenolic compounds
Tipo

article

original article