Leishmanicidal activity of fractions rich in aporphine alkaloids from Amazonian Unonopsis species


Autoria(s): Silva, Felipe M. A. da; Koolen, Hector H. F.; Lima, Janaína P. S. de; Santos, Delvânia M. F.; Jardim, Izaltina Silva; Souza, Afonso D. L. de; Pinheiro, Maria Lúcia Belém
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

04/11/2013

04/11/2013

2012

Resumo

In vitro evaluation of alkaloidal fractions of twigs, barks and leaves from two Unonopsis species, Unonopsis guatterioides R.E. Fr. and Unonopsis duckei R.E. Fr., Annonaceae, against promastigote forms of Leishmania amazonensis revealed these species as sources of substances with promising leishmanicidal potential. All alkaloidal fractions from twigs, barks and leaves of U. guatterioides were classified as highly active, with IC50 1.07, 1.90, and 2.79 mg/mL, respectively. Only the alkaloidal fraction from the twigs of U. duckei was classified as inactive.

Identificador

Rev. bras. farmacogn.,v.22,n.6,p.1368-1371,2012

0102-695X

http://www.producao.usp.br/handle/BDPI/39012

10.1590/S0102-695X2012005000103

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000600024&lng=en&nrm=iso&tlng=en

http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0102-695X2012000600024&lng=en&nrm=iso&tlng=en

http://www.scielo.br/scielo.php?script=sci_pdf&pid=S0102-695X2012000600024&lng=en&nrm=iso&tlng=en

Idioma(s)

eng

Publicador

Sociedade Brasileira de Farmacognosia

Relação

Revista Brasileira de Farmacognosia

Direitos

openAccess

Palavras-Chave #aporphine alkaloids #leishmanicidal activity #Unonopsis duckei #Unonopsis guatterioides
Tipo

article

original article