Anticholinesterase activity evaluation of alkaloids and coumarin from stems of Conchocarpus fontanesianus
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
04/11/2013
04/11/2013
2012
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Resumo |
Conchocarpus fontanesianus (A. St.-Hill.) Kallunki & Pirani, Rutaceae, popularly known as pitaguará, is a native and endemic tree from São Paulo and Rio de Janeiro States, Brazil. Based in the information that anticholinesterasic derivatives could act as new prototypes to treatment of Alzheimer disease, this work describes the fractionation guided by evaluation of the anticholinesterase activity of the ethanolic stems extract from C. fontanesianus. This procedure afforded the alkaloids dictamnine (1), γ-fagarine (2), skimianine (3), and 2-phenyl-1-methyl-4-quinolone (4), as well as the coumarin marmesin (5). |
Identificador |
Rev. bras. farmacogn.,v.22,n.2,p.374-380,2012 0102-695X http://www.producao.usp.br/handle/BDPI/38995 10.1590/S0102-695X2011005000219 http://www.scielo.br/scielo.php?script=sci_pdf&pid=S0102-695X2012000200018&lng=en&nrm=iso&tlng=en |
Idioma(s) |
eng |
Publicador |
Sociedade Brasileira de Farmacognosia |
Relação |
Revista Brasileira de Farmacognosia |
Direitos |
openAccess |
Palavras-Chave | #acetylcholinesterase inhibitors, alkaloids #Conchocarpus fontanesianus #coumarin Rutaceae |
Tipo |
article original article |