MTP -493G/T gene polymorphism is associated with steatosis in hepatitis C-infected patients
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
04/11/2013
04/11/2013
2012
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Resumo |
The reduction of hepatic microsomal transfer protein (MTP) activity results in fatty liver, worsening hepatic steatosis and fibrosis in chronic hepatitis C (CHC). The G allele of the MTP gene promoter, -493G/T, has been associated with lower transcriptional activity than the T allele. We investigated this association with metabolic and histological variables in patients with CHC. A total of 174 untreated patients with CHC were genotyped for MTP -493G/T by direct sequencing using PCR. All patients were negative for markers of Wilson’s disease, hemochromatosis and autoimmune diseases and had current and past daily alcohol intake lower than 100 g/week. The sample distribution was in Hardy-Weinberg equilibrium. Among subjects with genotype 1, 56.8% of the patients with fibrosis grade 3+4 presented at least one G allele versus 34.3% of the patients with fibrosis grade 1+2 (OR = 1.8; 95%CI = 1.3-2.3). Logistic regression analysis with steatosis as the dependent variable identified genotypes GG+GT as independent protective factors against steatosis (OR = 0.4, 95%CI = 0.2-0.8; P = 0.01). The results suggest that the presence of the G allele of MTP -493G/T associated with lower hepatic MTP expression protects against steatosis in our CHC patients. |
Identificador |
Braz J Med Biol Res,v.45,n.1,p.72-77,2012 0100-879X http://www.producao.usp.br/handle/BDPI/38756 10.1590/S0100-879X2011007500160 http://www.scielo.br/scielo.php?script=sci_pdf&pid=S0100-879X2012000100012&lng=en&nrm=iso&tlng=en |
Idioma(s) |
eng |
Publicador |
Associação Brasileira de Divulgação Científica |
Relação |
Brazilian Journal of Medical and Biological Research |
Direitos |
openAccess |
Palavras-Chave | #Hepatitis C #Steatosis #Fibrosis #Microsomal transfer protein |
Tipo |
article original article |