Surgical and postmortem pathology studies: contribution for the investigation of temporal lobe epilepsy


Autoria(s): Caboclo, Luís Otávio Sales Ferreira; Neves, Rafael Scarpa; Jardim, Anaclara Prada; Hamad, Ana Paula Andrade; Centeno, Ricardo Silva; Lancellotti, Carmen Lucia Penteado; Scorza, Carla Alessandra; Cavalheiro, Esper Abrão; Yacubian, Elza Márcia Targas; Sakamoto, Américo Ceiki
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

04/11/2013

04/11/2013

2012

Resumo

Pathology studies in epilepsy patients bring useful information for comprehending the physiopathology of various forms of epilepsy, as well as aspects related to response to treatment and long-term prognosis. These studies are usually restricted to surgical specimens obtained from patients with refractory focal epilepsies. Therefore, most of them pertain to temporal lobe epilepsy (TLE) with mesial temporal sclerosis (MTS) and malformations of cortical development (MCD), thus providing information of a selected group of patients and restricted regions of the brain. Postmortem whole brain studies are rarely performed in epilepsy patients, however they may provide extensive information on brain pathology, allowing the analysis of areas beyond the putative epileptogenic zone. In this article, we reviewed pathology studies performed in epilepsy patients with emphasis on neuropathological findings in TLE with MTS and MCD. Furthermore, we reviewed data from postmortem studies and discussed the importance of performing these studies in epilepsy populations.

Identificador

Arq. Neuro-Psiquiatr.,v.70,n.12,p.945-952,2012

0004-282X

http://www.producao.usp.br/handle/BDPI/38131

10.1590/S0004-282X2012001200009

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012001200009&lng=en&nrm=iso&tlng=en

http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0004-282X2012001200009&lng=en&nrm=iso&tlng=en

http://www.scielo.br/scielo.php?script=sci_pdf&pid=S0004-282X2012001200009&lng=en&nrm=iso&tlng=en

Idioma(s)

eng

Publicador

Academia Brasileira de Neurologia - ABNEURO

Relação

Arquivos de Neuro-Psiquiatria

Direitos

openAccess

Palavras-Chave #epilepsy #temporal lobe #mesial temporal sclerosis #pathology #surgical #epilepsia do lobo temporal #esclerose mesial temporal #patologia cirúrgica
Tipo

article

original article