Septic shock in older people: a prospective cohort study

Autoria(s): Pinheiro da Silva, Fabiano ; Zampieri, Fernando ; Barbeiro, Denise ; Barbeiro, Hermes ; Goulart, Alessandra Carvalho; Torggler Filho, Francisco ; Velasco, Irineu ; da Cruz Neto, Luiz ; de Souza, Heraldo ; Machado, Marcel Cerqueira 
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO
Data(s)

14/10/2013

14/10/2013

2013
Resumo

Abstract Background Septic shock is the first cause of death in Intensive Care Units. Despite experimental data showing increased inflammatory response of aged animals following infection, the current accepted hypothesis claims that aged patients are immunocompromised, when compared to young individuals. Results Here, we describe a prospective cohort study designed to analyze the immune profile of this population. Conclusion Older people are as immunocompetent as the young individual, regarding the cytokines, chemokines and growth factors response to devastating infection.

The current study is part of an ongoing prospective cohort study, designed to store clinical data and biological samples for multiple projects and conceived by HPS and LMCN (Brazilian Initiative for Sepsis Knowledge, BRISK Project).

FPS is supported by FAPESP, São Paulo Research Foundation (grant # 2009/17731-2).

We would like to express our gratitude to the patients and their families for consenting to participate in this study.
Identificador

Immunity & Ageing. Jun 10(1), 2013

1742-4933

http://www.producao.usp.br/handle/BDPI/34838

10.1186/1742-4933-10-21

http://www.immunityageing.com/content/10/1/21
Idioma(s)

eng
Relação

Immunity & Ageing
Direitos

openAccess

Pinheiro da Silva et al.; licensee BioMed Central Ltd. - This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Tipo

article
Acesso ao item digital