A Robust Structural PGN Model for Control of Cell-Cycle Progression Stabilized by Negative Feedbacks


Autoria(s): Trepode, Nestor ; Armelin, Hugo ; Bittner, Michael ; Barrera, Junior; Gubitoso, Marco Dimas; Hashimoto, Ronaldo Fumio
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

26/08/2013

26/08/2013

2007

Resumo

The cell division cycle comprises a sequence of phenomena controlled by a stable and robust genetic network. We applied a probabilistic genetic network (PGN) to construct a hypothetical model with a dynamical behavior displaying the degree of robustness typical of the biological cell cycle. The structure of our PGN model was inspired in well-established biological facts such as the existence of integrator subsystems, negative and positive feedback loops, and redundant signaling pathways. Our model represents genes interactions as stochastic processes and presents strong robustness in the presence of moderate noise and parameters fluctuations. A recently published deterministic yeast cell-cycle model does not perform as well as our PGN model, even upon moderate noise conditions. In addition, self stimulatory mechanisms can give our PGN model the possibility of having a pacemaker activity similar to the observed in the oscillatory embryonic cell cycle.

Identificador

1687-4153

http://www.producao.usp.br/handle/BDPI/33056

http://bsb.eurasipjournals.com/content/2007/1/73109

Idioma(s)

eng

Relação

EURASIP Journal on Bioinformatics and Systems Biology

Direitos

openAccess

Nestor Walter Trepode et al. - This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Tipo

article

original article