Epicolactone - Natural Product Isolated from the Sugarcane Endophytic Fungus Epicoccum nigrum
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
21/10/2013
21/10/2013
2012
|
| Resumo |
The endophytic fungus Epicoccum nigrum was isolated from sugarcane and the bioguided fractionation of the ethyl acetate extract led to the isolation of epicolactone, mellein, and 4,5-dimethylresorcinol. Characterization of epicolactone by MS, NMR and X-ray crystallography revealed a new natural product with an unusual carbon skeleton. The production of this secondary metabolite decreased in mutants of Epicoccum nigrum transformed by Agrobacterium tumefaciens. Additionally, these mutants produced 4-hydroxymellein. Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2010/08286-2] Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) Petrobras PETROBRAS |
| Identificador |
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, WEINHEIM, v. 756, n. 27, supl. 1, Part 6, pp. 5225-5230, SEP, 2012 1434-193X http://www.producao.usp.br/handle/BDPI/35335 10.1002/ejoc.201200757 |
| Idioma(s) |
eng |
| Publicador |
WILEY-V C H VERLAG GMBH WEINHEIM |
| Relação |
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY |
| Direitos |
closedAccess Copyright WILEY-V C H VERLAG GMBH |
| Palavras-Chave | #NATURAL PRODUCTS #BIOORGANIC CHEMISTRY #MUTAGENESIS #EPICOCCUM NIGRUM #POSTHARVEST BROWN-ROT #MEDIATED TRANSFORMATION #ABSOLUTE-CONFIGURATION #AGROBACTERIUM #BIOSYNTHESIS #PURPURASCENS #METABOLITES #BIOCONTROL #INHIBITOR #PHEROMONE #CHEMISTRY, ORGANIC |
| Tipo |
article original article publishedVersion |
