Low Bone Mineral Density in Middle-Aged Breast Cancer Survivors: Prevalence and Associated Factors
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
21/10/2013
21/10/2013
2012
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Resumo |
Background: The aim of this study was to investigate the prevalence of low bone mineral density (BMD) and associated factors in middle-aged breast cancer survivors (BCS). Patients and Methods: A cross-sectional study was conducted with 70 BCS of 45-65 years of age undergoing complete oncology treatment. Logistic regression models were used to identify factors associated with low BMD (osteopenia and osteoporosis taken together as a single group). Results: The mean age of participants was 53.2 +/- 5.9 years. BMD was low at the femoral neck in 28.6% of patients and at the lumbar spine in 45.7%. Body mass index <= 30 kg/m(2) (adjusted odds ratio (OR) 3.43; 95% confidence interval (CI) 1.0-11.3) and postmenopausal status (OR adjusted 20.42; 95% CI 2.0-201.2) were associated with low BMD at the lumbar spine. Femoral neck measurements, age > 50 years (OR 3.41; 95% CI 1.0-11.6), and time since diagnosis > 50 months (OR adjusted 3.34; 95% CI 1.0-11.3) increased the likelihood of low BMD. Conclusion: These findings show that low BMD is common in middle-aged BCS. Factors were identified that may affect BMD in BCS and should be considered when implementing strategies to minimize bone loss in middle-aged women with breast cancer. |
Identificador |
BREAST CARE, BASEL, v. 7, n. 2, supl. 1, Part 1, pp. 121-125, OCT, 2012 1661-3791 http://www.producao.usp.br/handle/BDPI/35384 10.1159/000337763 |
Idioma(s) |
eng |
Publicador |
KARGER BASEL |
Relação |
BREAST CARE |
Direitos |
closedAccess Copyright KARGER |
Palavras-Chave | #BREAST CANCER #MENOPAUSE #BONE MASS #OSTEOPOROSIS #MIDDLE-AGED WOMEN #POSTMENOPAUSAL WOMEN #FRACTURE RISK #ADJUVANT CHEMOTHERAPY #OSTEOPOROSIS #HEALTH #MANAGEMENT #TRIAL #MASS #ONCOLOGY #OBSTETRICS & GYNECOLOGY |
Tipo |
article original article publishedVersion |