The first report of the qnrB19, qnrS1 and aac(6 ')-Ib-cr genes in urinary isolates of ciprofloxacin-resistant Escherichia coli in Brazil
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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| Data(s) |
21/10/2013
21/10/2013
2012
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| Resumo |
In this study, we investigated the presence of plasmid-mediated quinolone resistance (PMQR) genes among 101 ciprofloxacin-resistant urinary Escherichia coli isolates and searched for mutations in the quinolone-resistance-determining regions (QRDRs) of the DNA gyrase and topoisomerase IV genes in PMQR-carrying isolates. Eight isolates harboured the qnr and aac(6')-Ib-cr genes (3 qnrS1, 1 qnrB19 and 4 aac(6')-Ib-cr). A mutational analysis of the QRDRs in qnr and aac(6')-Ib-cr-positive isolates revealed mutations in gyrA, parC and parE that might be associated with high levels of resistance to quinolones. No mutation was detected in gyrB. Rare gyrA, parC and parE mutations were detected outside of the QRDRs. This is the first report of qnrB19, qnrS1 and aac(6')-Ib-cr-carrying E. coli isolates in Brazil. CNPq [475024/2009-5] FAPEMIG [01401-10] Pro-Reitoria de Pesquisa/UFMG |
| Identificador |
MEMORIAS DO INSTITUTO OSWALDO CRUZ, RIO DE JANEIRO, RJ, v. 107, n. 5, supl., Part 3, pp. 687-689, AUG, 2012 0074-0276 http://www.producao.usp.br/handle/BDPI/35394 10.1590/S0074-02762012000500018 |
| Idioma(s) |
eng |
| Publicador |
FUNDACO OSWALDO CRUZ RIO DE JANEIRO, RJ |
| Relação |
MEMORIAS DO INSTITUTO OSWALDO CRUZ |
| Direitos |
openAccess Copyright FUNDACO OSWALDO CRUZ |
| Palavras-Chave | #QNRS1 #QNRB19 #AAC(6 ')-IB-CR #MEDIATED QUINOLONE RESISTANCE #FLUOROQUINOLONE RESISTANCE #KLEBSIELLA-PNEUMONIAE #MODIFYING ENZYME #UNITED-STATES #PLASMID #DETERMINANTS #ENTEROBACTERIACEAE #PREVALENCE #SALMONELLA #PARASITOLOGY #TROPICAL MEDICINE |
| Tipo |
article original article publishedVersion |
