Populene D Analogues: Design, Concise Synthesis and Antiproliferative Activity
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
21/10/2013
21/10/2013
2012
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| Resumo |
An efficient and concise synthesis of nine populene D analogues was performed using an iodine-catalyzed Prins cyclization as the key transformation. The antiproliferative activity of these new pyrans against several cancer cell lines was then investigated. Among them, an isochromene with moderate activity (mean logGI(50) = 0.91) was found. Additionally, compounds with selectivity toward the tumor cell lines NCI-ADR/RES, OVCAR-3, and HT29 were discovered. CAPES CAPES CNPq CNPq FAPESP FAPESP |
| Identificador |
MOLECULES, BASEL, v. 17, n. 8, supl. 1, Part 1, pp. 9621-9630, AUG, 2012 1420-3049 http://www.producao.usp.br/handle/BDPI/35406 10.3390/molecules17089621 |
| Idioma(s) |
eng |
| Publicador |
MDPI AG BASEL |
| Relação |
MOLECULES |
| Direitos |
openAccess Copyright MDPI AG |
| Palavras-Chave | #OSOCHROMENE #PYRANS #PRINS CYCLIZATION #IODINE #ANTIPROLIFERATIVE #CANCER #ANTICANCER DRUG SCREEN #NATURAL-PRODUCTS #DISCOVERY #SPONGE #PLANTS #CHEMISTRY, ORGANIC |
| Tipo |
article original article publishedVersion |
