Analysis of the mRNA expression of the S100 beta protein in adipocytes of patients with diabetes mellitus, type 2
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
07/11/2013
07/11/2013
2012
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Resumo |
Objective: This study aims to explore the possible relationship between the expression level of S100 beta protein mRNA with diabetes mellitus type 2 in adipocytes from patients with this disease in comparison with normoglycemic individuals. Materials and methods: Samples of adipose tissue of eight patients from the coronary section of the Institute Dante Pazzanese of Cardiology (IDPC), four in Group Diabetes and four of Normoglycemic group, were evaluated by RT-PCR real time. Results: An increase around 15 times values, between the threshold cycle (Delta Ct), of mRNA expression of S100 beta protein in adipocytes of the diabetes group was observed in comparison to the control group (p = 0.015). Conclusion: Our results indicate, for the first time, that there is coexistence of increased expression of the S100 beta and the type 2 diabetes mellitus gene. Arq Bras Endocrinol Metab. 2012;56(7):435-40 |
Identificador |
ARQUIVOS BRASILEIROS DE ENDOCRINOLOGIA E METABOLOGIA, RIO DE JANEIRO, RJ, v. 56, n. 7, pp. 435-440, OCT, 2012 0004-2730 http://www.producao.usp.br/handle/BDPI/42868 10.1590/S0004-27302012000700005 |
Idioma(s) |
por |
Publicador |
SBEM-SOC BRASIL ENDOCRINOLOGIA & METABOLOGIA RIO DE JANEIRO, RJ |
Relação |
ARQUIVOS BRASILEIROS DE ENDOCRINOLOGIA E METABOLOGIA |
Direitos |
openAccess Copyright SBEM-SOC BRASIL ENDOCRINOLOGIA & METABOLOGIA |
Palavras-Chave | #DIABETES #S100BETA #RT-PCR #ADIPOCYTES #BIOMARKER #CALCIUM-BINDING PROTEINS #EF-HAND TYPE #FUNCTIONAL ROLES #S100 PROTEINS #IN-VIVO #RECEPTOR #CELLS #FAMILY #BRAIN #GENE #ENDOCRINOLOGY & METABOLISM |
Tipo |
article original article publishedVersion |