Giant cell bone lesions in the craniofacial region: a diagnostic and therapeutic challenge


Autoria(s): Borges, Bruno Barros Pinto; Fornazieri, Marco Aurelio; Bezerra, Ana Paula Correia de Araújo; Martins, Leandro Aurelio Liporoni; Pinna, Fabio de Rezende; Voegels, Richard Louis
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

07/11/2013

07/11/2013

2012

Resumo

Background: Giant cell tumors of bone (GCTs) are common in the long bones, but rare in the craniofacial region, with only 1% of cases occurring in the latter. Clinical, radiological, and anatomical diagnosis of this locally aggressive disease, which occurs in response to trauma or neoplastic transformation, poses a major challenge in clinical practice. Methods: The present study describes a series of 4 cases and highlights the main features of the differential diagnosis and treatment of these lesions: GCT, giant cell reparative granuloma (GCRG), and the brown tumor of hyperparathyroidism. Results: GCT presents as a benign neoplasm, most typically affecting the knees, and rarely in the temporal and sphenoid bones. It is radiologically indistinguishable from GCRG due to its lytic, poorly defined appearance. The distinction can only be made microscopically, as the presence of multinucleated giant cells scattered throughout the stroma and the absence of a history of trauma favor a diagnosis of GCT. The brown tumor of hyperparathyroidism occurs with rapid, localized osteoclast activity secondary to the effects of increased parathyroid hormone (PTH) levels; parathyroid examination is indispensable. Conclusion: The diagnosis and treatment of these lesions poses a major challenge due to their similar clinical presentation and radiological appearance. Accurate diagnosis is essential for definition of appropriate management, as complete resection is the goal in GCT and GCRG to avoid recurrence, whereas the brown tumor often yields to treatment of the underlying hyperparathyroidism.

Identificador

INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY, HOBOKEN, v. 2, n. 6, pp. 501-506, NOV-DEC, 2012

2042-6976

http://www.producao.usp.br/handle/BDPI/42736

10.1002/alr.21050

http://dx.doi.org/10.1002/alr.21050

Idioma(s)

eng

Publicador

WILEY-BLACKWELL

HOBOKEN

Relação

INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY

Direitos

closedAccess

Copyright WILEY-BLACKWELL

Palavras-Chave #GIANT CELL TUMORS #GIANT CELL GRANULOMA #BROWN TUMOR #CRANIOFACIAL REGION #BONE NEOPLASMS #REPARATIVE GRANULOMA #TUMOR #OTORHINOLARYNGOLOGY
Tipo

article

original article

publishedVersion