Toward supramolecular architectures of the anti-HIV drug lamivudine: understanding the effect of the inclusion of water in a hydrochloride form
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
06/11/2013
06/11/2013
2012
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| Resumo |
Two salts of the anti-HIV drug lamivudine, namely, lamivudine hydrochloride and lamivudine hydrochloride monohydrate, were prepared for the first time. Structural relationships and the role of water in crystal assembly and lamivudine conformation were established and allowed for a rational approach to understand how solid state properties could be changed by engineering new salts of the drug. Brazilian Research Council CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico) Brazilian Research Council CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico) [472623/2011-7] Consejo Superior de Investigaciones Cientificas (CSIC) of Spain Consejo Superior de Investigaciones Cientificas (CSIC) of Spain |
| Identificador |
CRYSTENGCOMM, CAMBRIDGE, v. 14, n. 7, supl. 1, Part 3, pp. 2373-2376, NOV-DEC, 2012 1466-8033 http://www.producao.usp.br/handle/BDPI/42704 10.1039/c2ce06303d |
| Idioma(s) |
eng |
| Publicador |
ROYAL SOC CHEMISTRY CAMBRIDGE |
| Relação |
CRYSTENGCOMM |
| Direitos |
openAccess Copyright ROYAL SOC CHEMISTRY |
| Palavras-Chave | #ACTIVE PHARMACEUTICAL INGREDIENTS #CO-CRYSTALS #DESIGN #CHEMISTRY, MULTIDISCIPLINARY #CRYSTALLOGRAPHY |
| Tipo |
article original article publishedVersion |
