Polymorphisms in Inflammasome' Genes and Susceptibility to HIV-1 Infection
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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| Data(s) |
06/11/2013
06/11/2013
2012
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| Resumo |
The involvement of inflammasome genes in the susceptibility to HIV-1 infection was investigated. Twelve single nucleotide polymorphisms within NLRP1, NLRP3, NLRC4, CARD8, CASP1, and IL1B genes were analyzed in 150 HIV-1-infected Brazilian subjects and 158 healthy controls. The 2 polymorphisms rs10754558 in NLRP3 and rs1143634 in IL1B were significantly associated to the HIV-1 infection. These findings supported the previously hypothesized involvement of NALP3-inflammasome in HIV-1 pathogenesis, underlining once more the key role of inflammation and innate immunity in the susceptibility to HIV-1 infection. Sao Paulo Research foundation (FAPESP) [09/53575-5] Sao Paulo Research Foundation (FAPESP) Pernambuco Research foundation (FACEPE) [APQ-0757-2.02/10] Pernambuco Research foundation (FACEPE) IRCCS "Burlo Garofolo", Trieste, Italy [RC 07/08] IRCCS Burlo Garofolo (Trieste, Italy) TALENTS Program (7th R&D Framework Program, Specific Program: PEOPLEMarie Curie ActionsCOFUND) TALENTS Program (7th R&D Framework Program, Specific Program: PEOPLE-Marie Curie Actions-COFUND) |
| Identificador |
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, PHILADELPHIA, v. 59, n. 2, supl. 1, Part 1, pp. 121-125, FEB 1, 2012 1525-4135 http://www.producao.usp.br/handle/BDPI/42698 10.1097/QAI.0b013e3182392ebe |
| Idioma(s) |
eng |
| Publicador |
LIPPINCOTT WILLIAMS & WILKINS PHILADELPHIA |
| Relação |
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES |
| Direitos |
closedAccess Copyright LIPPINCOTT WILLIAMS & WILKINS |
| Palavras-Chave | #GENETICS #HIV-1 #INFLAMMASOME #IL-1 BETA #INNATE IMMUNITY #NALP3/NLRP3 #POLYMORPHISMS #DISEASE #IMMUNITY #CCL3L1 #IMMUNOLOGY #INFECTIOUS DISEASES |
| Tipo |
article original article publishedVersion |
