Early skin immunological disturbance after Plasmodium-infected mosquito bites
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
05/11/2013
05/11/2013
2012
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Resumo |
Although the role of regulatory T cells (Tregs) during malaria infection has been studied extensively, such studies have focused exclusively on the role of Treg during the blood stage of infection; little is known about the detailed mechanisms of Tregs and sporozoite deposition in the dermis by mosquito bites. In this paper we show that sporozoites introduced into the skin by mosquito bites increase the mobility of skin Tregs and dendritic cells (DCs). We also show differences in MHC class II and/or C086 expression on skin-resident dendritic cell subtypes and macrophages. From the observed decrease of the number of APCs into draining lymph nodes, suppression of CD28 expression in conventional CD4 T cells, and a low homeostatic proliferation of skin-migrated CD4 T found in nude mice indicate that Tregs may play a fundamental role during the initial phase of malaria parasite inoculation into the mammalian host. (C) 2012 Elsevier Inc. All rights reserved. FCT grant FCT grant [PTDC/EBB-BIO/115514/2009] CAPESFCT CAPES-FCT [258/2010] |
Identificador |
CELLULAR IMMUNOLOGY, SAN DIEGO, v. 277, n. 41306, supl. 4, Part 1-2, pp. 22-32, MAY-JUN, 2012 0008-8749 http://www.producao.usp.br/handle/BDPI/41536 10.1016/j.cellimm.2012.06.003 |
Idioma(s) |
eng |
Publicador |
ACADEMIC PRESS INC ELSEVIER SCIENCE SAN DIEGO |
Relação |
CELLULAR IMMUNOLOGY |
Direitos |
closedAccess Copyright ACADEMIC PRESS INC ELSEVIER SCIENCE |
Palavras-Chave | #REGULATORY T CELL #PLASMODIUM BERGHEI #DENDRITIC CELL #SKIN #IMMUNITY #REGULATORY T-CELLS #DENDRITIC CELLS #MALARIA PARASITE #PROLIFERATION #INFLAMMATION #SPOROZOITES #TOLERANCE #MIGRATION #IMMUNITY #CTLA-4 #CELL BIOLOGY #IMMUNOLOGY |
Tipo |
article original article publishedVersion |