An in-depth analysis of the HIV-1/AIDS dynamics by comprehensive mathematical modeling
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
05/11/2013
05/11/2013
2012
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| Resumo |
This work presents major results from a novel dynamic model intended to deterministically represent the complex relation between HIV-1 and the human immune system. The novel structure of the model extends previous work by representing different host anatomic compartments under a more in-depth cellular and molecular immunological phenomenology. Recently identified mechanisms related to HIV-1 infection as well as other well known relevant mechanisms typically ignored in mathematical models of HIV-1 pathogenesis and immunology, such as cell-cell transmission, are also addressed. (C) 2011 Elsevier Ltd. All rights reserved. FAPESP FAPESP [99/09897-4] |
| Identificador |
MATHEMATICAL AND COMPUTER MODELLING, OXFORD, v. 55, n. 41367, supl. 1, Part 3, pp. 342-366, FEB, 2012 0895-7177 http://www.producao.usp.br/handle/BDPI/41565 10.1016/j.mcm.2011.08.008 |
| Idioma(s) |
eng |
| Publicador |
PERGAMON-ELSEVIER SCIENCE LTD OXFORD |
| Relação |
MATHEMATICAL AND COMPUTER MODELLING |
| Direitos |
closedAccess Copyright PERGAMON-ELSEVIER SCIENCE LTD |
| Palavras-Chave | #HIV-1/AIDS INFECTION #MATHEMATICAL MODEL #COMPUTATIONAL SIMULATION #HUMAN-IMMUNODEFICIENCY-VIRUS #PRIMARY HIV-INFECTION #ACTIVE ANTIRETROVIRAL THERAPY #MONOCYTE-DERIVED MACROPHAGES #T-CELL #POPULATION-DYNAMICS #IMMUNE-RESPONSES #TYPE-1 INFECTION #LYMPHOCYTES #TRANSMISSION #COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS #COMPUTER SCIENCE, SOFTWARE ENGINEERING #MATHEMATICS, APPLIED |
| Tipo |
article original article publishedVersion |
