Matrix metalloproteinases, tissue inhibitors of metalloproteinases, and growth factors regulate the aggressiveness and proliferative activity of keratocystic odontogenic tumors


Autoria(s): Ribeiro Ribeiro, Andre Luis; Nobre, Rafaela M.; Alves Junior, Sergio M.; Kataoka, Maria S. S.; Barroso, Regina F. F.; Jaeger, Ruy G.; Pinheiro, Joao J. V.
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

10/10/2013

10/10/2013

01/10/2012

Resumo

Objective. The objective of this preliminary study was to evaluate the expression of matrix metalloproteinases (MMPs), tissue inhibitors of metalloproteinases (TIMPs) and growth factors in keratocystic odontogenic tumors (KOTs). Study Design. The expression of MMPs, TIMPs, growth factors, and the extracellular signal-regulated kinase (ERK) 1/2 signaling pathway were assessed by immunohistochemistry in 15 cases of KOT and 4 cases of calcifying cystic odontogenic tumor (CCOT). Results. KOT samples expressed significantly higher amounts of MMPs, TIMPs, growth factors, epidermal growth factor receptor (EGFR), and ERK compared with CCOT samples, with the exception of MMP-2 and TIMP-1. Conclusions. MMP-9, TIMP-2, EGF and transforming growth factor alpha act together and likely regulate the proliferation and aggressiveness of KOT. ERK-1/2 serves as the transducer of signals generated by these proteins, which signal through the common receptor, EGFR. This process may be related to the increased proliferation and aggressiveness observed in KOT. (Oral Surg Oral Med Oral Pathol Oral Radiol 2012;114:487-496)

Identificador

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY, NEW YORK, v. 114, n. 4, pp. 487-496, OCT, 2012

2212-4403

http://www.producao.usp.br/handle/BDPI/34103

10.1016/j.oooo.2012.06.011

http://dx.doi.org/10.1016/j.oooo.2012.06.011

Idioma(s)

eng

Publicador

ELSEVIER SCIENCE INC

NEW YORK

Relação

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

Direitos

restrictedAccess

Copyright ELSEVIER SCIENCE INC

Palavras-Chave #BENIGN CYSTIC NEOPLASM #IMMUNOHISTOCHEMICAL EXPRESSION #EXTRACELLULAR-MATRIX #CANCER #KINASE #AMELOBLASTOMA #PROTEINS #BEHAVIOR #FEATURES #MT1-MMP #DENTISTRY, ORAL SURGERY & MEDICINE
Tipo

article

original article

publishedVersion