RGMa and RGMb expression pattern during chicken development suggest unexpected roles for these repulsive guidance molecules in notochord formation, somitogenesis, and myogenesis
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
07/11/2013
07/11/2013
2012
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Resumo |
Background: Repulsive guidance molecules (RGM) are high-affinity ligands for the Netrin receptor Neogenin, and they are crucial for nervous system development including neural tube closure; neuronal and neural crest cell differentiation and axon guidance. Recent studies implicated RGM molecules in bone morphogenetic protein signaling, which regulates a variety of developmental processes. Moreover, a role for RGMc in iron metabolism has been established. This suggests that RGM molecules may play important roles in non-neural tissues. Results: To explore which tissues and processed may be regulated by RGM molecules, we systematically investigated the expression of RGMa and RGMb, the only RGM molecules currently known for avians, in the chicken embryo. Conclusions: Our study suggests so far unknown roles of RGM molecules in notochord, somite and skeletal muscle development. Developmental Dynamics, 2012. (C) 2012 Wiley Periodicals, Inc. AFM AFM CNPq CNPq FAPESP FAPESP |
Identificador |
DEVELOPMENTAL DYNAMICS, HOBOKEN, v. 241, n. 12, Special Issue, supl. 1, Part 1, pp. 1886-1900, DEC, 2012 1058-8388 http://www.producao.usp.br/handle/BDPI/42799 10.1002/dvdy.23889 |
Idioma(s) |
eng |
Publicador |
WILEY-BLACKWELL HOBOKEN |
Relação |
DEVELOPMENTAL DYNAMICS |
Direitos |
closedAccess Copyright WILEY-BLACKWELL |
Palavras-Chave | #RGMA #DRAGON #RGMB #CHICKEN #EMBRYO #NEURAL PLATE, NEUROGENESIS #DORSAL ROOT GANGLIA #PHARYNGEAL ECTODERM #NOTOCHORD #SOMITE #DERMOMYOTOME #MYOTOME #MORPHOGENETIC PROTEIN CORECEPTOR #REGULATES HEPCIDIN EXPRESSION #PROGENITOR-CELL IDENTITY #NEURAL-TUBE CLOSURE #DORSAL SPINAL-CORD #SONIC HEDGEHOG #RECEPTOR NEOGENIN #SKELETAL-MUSCLE #MOUSE EMBRYO #NEURONAL DIFFERENTIATION #ANATOMY & MORPHOLOGY #DEVELOPMENTAL BIOLOGY |
Tipo |
article original article publishedVersion |