RGMa and RGMb expression pattern during chicken development suggest unexpected roles for these repulsive guidance molecules in notochord formation, somitogenesis, and myogenesis


Autoria(s): Jorge, Erika Cristina; Ahmed, Mohi U.; Bothe, Ingo; Coutinho, Luiz Lehmman; Dietrich, Susanne
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

07/11/2013

07/11/2013

2012

Resumo

Background: Repulsive guidance molecules (RGM) are high-affinity ligands for the Netrin receptor Neogenin, and they are crucial for nervous system development including neural tube closure; neuronal and neural crest cell differentiation and axon guidance. Recent studies implicated RGM molecules in bone morphogenetic protein signaling, which regulates a variety of developmental processes. Moreover, a role for RGMc in iron metabolism has been established. This suggests that RGM molecules may play important roles in non-neural tissues. Results: To explore which tissues and processed may be regulated by RGM molecules, we systematically investigated the expression of RGMa and RGMb, the only RGM molecules currently known for avians, in the chicken embryo. Conclusions: Our study suggests so far unknown roles of RGM molecules in notochord, somite and skeletal muscle development. Developmental Dynamics, 2012. (C) 2012 Wiley Periodicals, Inc.

AFM

AFM

CNPq

CNPq

FAPESP

FAPESP

Identificador

DEVELOPMENTAL DYNAMICS, HOBOKEN, v. 241, n. 12, Special Issue, supl. 1, Part 1, pp. 1886-1900, DEC, 2012

1058-8388

http://www.producao.usp.br/handle/BDPI/42799

10.1002/dvdy.23889

http://dx.doi.org/10.1002/dvdy.23889

Idioma(s)

eng

Publicador

WILEY-BLACKWELL

HOBOKEN

Relação

DEVELOPMENTAL DYNAMICS

Direitos

closedAccess

Copyright WILEY-BLACKWELL

Palavras-Chave #RGMA #DRAGON #RGMB #CHICKEN #EMBRYO #NEURAL PLATE, NEUROGENESIS #DORSAL ROOT GANGLIA #PHARYNGEAL ECTODERM #NOTOCHORD #SOMITE #DERMOMYOTOME #MYOTOME #MORPHOGENETIC PROTEIN CORECEPTOR #REGULATES HEPCIDIN EXPRESSION #PROGENITOR-CELL IDENTITY #NEURAL-TUBE CLOSURE #DORSAL SPINAL-CORD #SONIC HEDGEHOG #RECEPTOR NEOGENIN #SKELETAL-MUSCLE #MOUSE EMBRYO #NEURONAL DIFFERENTIATION #ANATOMY & MORPHOLOGY #DEVELOPMENTAL BIOLOGY
Tipo

article

original article

publishedVersion