Both the dorsal hippocampus and the dorsolateral striatum are needed for rat navigation in the Morris water maze


Autoria(s): Miyoshi, Edmar; Wietzikoski, Evellyn Claudia; Bortolanza, Mariza; Boschen, Suelen Lucio; Canteras, Newton Sabino; Izquierdo, Ivan; Da Cunha, Claudio
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

07/11/2013

07/11/2013

2012

Resumo

The multiple memory systems theory proposes that the hippocampus and the dorsolateral striatum are the core structures of the spatial/relational and stimulus-response (S-R) memory systems, respectively. This theory is supported by double dissociation studies showing that the spatial and cue (S-R) versions of the Morris water maze are impaired by lesions in the dorsal hippocarnpus and dorsal striatum, respectively. In the present study we further investigated whether adult male Wistar rats bearing double and bilateral electrolytic lesions in the dorsal hippocampus and dorsolateral striatum were as impaired as rats bearing single lesions in just one of these structures in learning both versions of the water maze. Such a prediction, based on the multiple memory systems theory, was not confirmed. Compared to the controls, the animals with double lesions exhibited no improvement at all in the spatial version and learned the cued version very slowly. These results suggest that, instead of independent systems competing for holding control over navigational behaviour, the hippocampus and dorsal striatum both play critical roles in navigation based on spatial or cue-based strategies. (C) 2011 Elsevier B.V. All rights reserved.

CNPq

CNPq

CAPES

CAPES

Fundacao Araucaria

Fundacao Araucaria

FAPESP

FAPESP

Identificador

BEHAVIOURAL BRAIN RESEARCH, AMSTERDAM, v. 226, n. 1, supl. 1, Part 3, pp. 171-178, 36892, 2012

0166-4328

http://www.producao.usp.br/handle/BDPI/43036

10.1016/j.bbr.2011.09.011

http://dx.doi.org/10.1016/j.bbr.2011.09.011

Idioma(s)

eng

Publicador

ELSEVIER SCIENCE BV

AMSTERDAM

Relação

BEHAVIOURAL BRAIN RESEARCH

Direitos

closedAccess

Copyright ELSEVIER SCIENCE BV

Palavras-Chave #BASAL GANGLIA #MEMORY #SPATIAL LEARNING #CUE LEARNING #WATER MAZE #MEMORY SYSTEMS INTERACTION #CAUDATE-NUCLEUS LESIONS #MULTIPLE MEMORY-SYSTEMS #ELEMENT-BINDING PROTEIN #DECISION-MAKING #PLACE #ACQUISITION #BRAIN #INACTIVATION #DISSOCIATION #COMPETITION #BEHAVIORAL SCIENCES #NEUROSCIENCES
Tipo

article

original article

publishedVersion