Both the dorsal hippocampus and the dorsolateral striatum are needed for rat navigation in the Morris water maze
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
07/11/2013
07/11/2013
2012
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Resumo |
The multiple memory systems theory proposes that the hippocampus and the dorsolateral striatum are the core structures of the spatial/relational and stimulus-response (S-R) memory systems, respectively. This theory is supported by double dissociation studies showing that the spatial and cue (S-R) versions of the Morris water maze are impaired by lesions in the dorsal hippocarnpus and dorsal striatum, respectively. In the present study we further investigated whether adult male Wistar rats bearing double and bilateral electrolytic lesions in the dorsal hippocampus and dorsolateral striatum were as impaired as rats bearing single lesions in just one of these structures in learning both versions of the water maze. Such a prediction, based on the multiple memory systems theory, was not confirmed. Compared to the controls, the animals with double lesions exhibited no improvement at all in the spatial version and learned the cued version very slowly. These results suggest that, instead of independent systems competing for holding control over navigational behaviour, the hippocampus and dorsal striatum both play critical roles in navigation based on spatial or cue-based strategies. (C) 2011 Elsevier B.V. All rights reserved. CNPq CNPq CAPES CAPES Fundacao Araucaria Fundacao Araucaria FAPESP FAPESP |
Identificador |
BEHAVIOURAL BRAIN RESEARCH, AMSTERDAM, v. 226, n. 1, supl. 1, Part 3, pp. 171-178, 36892, 2012 0166-4328 http://www.producao.usp.br/handle/BDPI/43036 10.1016/j.bbr.2011.09.011 |
Idioma(s) |
eng |
Publicador |
ELSEVIER SCIENCE BV AMSTERDAM |
Relação |
BEHAVIOURAL BRAIN RESEARCH |
Direitos |
closedAccess Copyright ELSEVIER SCIENCE BV |
Palavras-Chave | #BASAL GANGLIA #MEMORY #SPATIAL LEARNING #CUE LEARNING #WATER MAZE #MEMORY SYSTEMS INTERACTION #CAUDATE-NUCLEUS LESIONS #MULTIPLE MEMORY-SYSTEMS #ELEMENT-BINDING PROTEIN #DECISION-MAKING #PLACE #ACQUISITION #BRAIN #INACTIVATION #DISSOCIATION #COMPETITION #BEHAVIORAL SCIENCES #NEUROSCIENCES |
Tipo |
article original article publishedVersion |