ANTI-TRYPANOSOMAL ACTIVITY OF 1,2,3,4,6-PENTA-O-GALLOYL-beta-D-GLUCOSE ISOLATED FROM Plectranthus barbatus Andrews (Lamiaceae)
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
06/11/2013
06/11/2013
2012
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| Resumo |
MeOH extract from the leaves of Plectranthus barbatus Andrews (Lamiaceae), showed in vitro anti-trypanosomal activity. The bioassay-guided fractionation resulted in the isolation of a gallic acid derivative, identified as 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG), after thorough NMR and MS spectral analysis. Finally, this compound was tested against trypomastigote forms of T. cruzi and displayed an EC50 value of 67 mu M, at least 6.6-fold more effective than the standard drug benznidazole. This is the first occurrence of PGG in the Plectranthus genus and the first anti-parasitic activity described for PGG in the literature. FAPESP CNPq CAPES PIBIC/UNIFESP |
| Identificador |
QUIMICA NOVA, SAO PAULO, v. 35, n. 11, pp. 2229-2232, JUL-AUG, 2012 0100-4042 http://www.producao.usp.br/handle/BDPI/42415 10.1590/S0100-40422012001100025 |
| Idioma(s) |
eng |
| Publicador |
SOC BRASILEIRA QUIMICA SAO PAULO |
| Relação |
QUIMICA NOVA |
| Direitos |
openAccess Copyright SOC BRASILEIRA QUIMICA |
| Palavras-Chave | #PLECTRANTHUS BARBATUS #1,2,3,4,6-PENTA-O-GALLOYL-BETA-D-GLUCOSE #ANTI-TRYPANOSOMAL ACTIVITY #ANTIMICROBIAL ABIETANE #DITERPENOIDS #ANTIBACTERIAL #CHEMOTHERAPY #ASTERACEAE #PLANTS #DRUGS #CHEMISTRY, MULTIDISCIPLINARY |
| Tipo |
article original article publishedVersion |
