Metalloporphyrins as cytochrome P450 models for chlorhexidine metabolite prediction
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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| Data(s) |
06/11/2013
06/11/2013
2012
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| Resumo |
The catalytic oxidation of chlorhexidine (CHX, a strong microbicidal agent) mediated by ironporphyrins has been investigated by using hydrogen peroxide, mCPBA, tBuOOH, or NaOCl as oxidant. All of these oxygen donors yielded p-chloroaniline (pCA) as the main product. The higher pCA yields amounted to 71% in the following conditions: catalyst/oxidant/substrate molar ratio of 1:150:50, aqueous medium, FeTMPyP as catalyst. The medium pH also had a strong effect on the pCA yields; in physiological pH, formation of this product was specially favored in the presence of the catalysts, with yields 58% higher than those achieved in control reactions. This provided strong evidence that CHX is metabolized to pCA upon ingestion. (c) 2012 Elsevier B.V. All rights reserved. FAPESP FAPESP CAPES CAPES CNPq CNPq |
| Identificador |
APPLIED CATALYSIS A-GENERAL, AMSTERDAM, v. 447, n. 41398, supl. 1, Part 1, pp. 7-13, DEC 7, 2012 0926-860X http://www.producao.usp.br/handle/BDPI/42488 10.1016/j.apcata.2012.08.026 |
| Idioma(s) |
eng |
| Publicador |
ELSEVIER SCIENCE BV AMSTERDAM |
| Relação |
APPLIED CATALYSIS A-GENERAL |
| Direitos |
closedAccess Copyright ELSEVIER SCIENCE BV |
| Palavras-Chave | #BIOMIMETIC MODELS #METALLOPORPHYRINS #CYTOCHROME P450 #CHLORHEXIDINE #SODIUM-HYPOCHLORITE #ANTIBACTERIAL EFFICACY #HPLC DETERMINATION #PARA-CHLOROANILINE #P-CHLOROANILINE #GLUCONATE #OXIDATION #4-CHLOROANILINE #PREVENTION #TOXICITY #CHEMISTRY, PHYSICAL #ENVIRONMENTAL SCIENCES |
| Tipo |
article original article publishedVersion |
