Cytogenetic findings in pediatric radiation-induced atypical meningioma after treatment of medulloblastoma: case report and review of the literature
UNIVERSIDADE DE SÃO PAULO
Ionizing radiation is the most recognized risk factor for meningioma in pediatric long-term cancer survivors. Information in this rare setting is exceptional. We report the clinical and cytogenetic findings in a radiation-induced atypical meningioma following treatment for desmoplastic medulloblastoma in a child. This is the second study to describe the cytogenetic aspects on radiation-induced meningiomas in children. Chromosome banding analysis revealed a 46, XX, t(1;3)(p22;q12), del(1)(p?)/46, XX. Loss of chromosome 1p as a consequence of irradiation has been proposed to be more important in the development of secondary meningiomas in adults. Deletions in the short arm of chromosome 1 also appear to be a shared feature in both pediatric cases so far analyzed.
Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2010/15,717-0]
Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
JOURNAL OF NEURO-ONCOLOGY, NEW YORK, v. 110, n. 3, supl. 1, Part 3, pp. 397-402, DEC, 2012
JOURNAL OF NEURO-ONCOLOGY
|Palavras-Chave||#RADIATION-INDUCED MENINGIOMA #CHILDREN #CYTOGENETICS #1P #IN-SITU HYBRIDIZATION #CENTRAL-NERVOUS-SYSTEM #MALIGNANT PROGRESSION #YOUNG-CHILDREN #CHEMOTHERAPY #CHROMOSOMES #ABERRATIONS #GLUCOSE-TRANSPORTER-1 #IDENTIFICATION #IRRADIATION #ONCOLOGY #CLINICAL NEUROLOGY|