Cortical activation during executed, imagined, observed, and passive wrist movements in healthy volunteers and stroke patients
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
06/11/2013
06/11/2013
2012
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Resumo |
Motor imagery, passive movement, and movement observation have been suggested to activate the sensorimotor system without overt movement. The present study investigated these three covert movement modes together with overt movement in a within-subject design to allow for a fine-grained comparison of their abilities in activating the sensorimotor system, i.e. premotor, primary motor, and somatosensory cortices. For this, 21 healthy volunteers underwent functional magnetic resonance imaging (fMRI). In addition we explored the abilities of the different covert movement modes in activating the sensorimotor system in a pilot study of 5 stroke patients suffering from chronic severe hemiparesis. Results demonstrated that while all covert movement modes activated sensorimotor areas, there were profound differences between modes and between healthy volunteers and patients. In healthy volunteers, the pattern of neural activation in overt execution was best resembled by passive movement, followed by motor imagery, and lastly by movement observation. In patients, attempted overt execution was best resembled by motor imagery, followed by passive movement and lastly by movement observation. Our results indicate that for severely hemiparetic stroke patients motor imagery may be the preferred way to activate the sensorimotor system without overt behavior. In addition, the clear differences between the covert movement modes point to the need for within-subject comparisons. (C) 2012 Elsevier Inc. All rights reserved. Medical Research Council, UK [CEG 61501] |
Identificador |
NEUROIMAGE, SAN DIEGO, v. 62, n. 1, pp. 266-280, AUG, 2012 1053-8119 http://www.producao.usp.br/handle/BDPI/42301 10.1016/j.neuroimage.2012.05.009 |
Idioma(s) |
eng |
Publicador |
ACADEMIC PRESS INC ELSEVIER SCIENCE SAN DIEGO |
Relação |
NEUROIMAGE |
Direitos |
closedAccess Copyright ACADEMIC PRESS INC ELSEVIER SCIENCE |
Palavras-Chave | #NEUROREHABILITATION #MOVEMENT SIMULATION #MOTOR IMAGERY #MOVEMENT OBSERVATION #PASSIVE MOVEMENT #OVERT EXECUTION #POSITRON-EMISSION-TOMOGRAPHY #MIRROR NEURON SYSTEM #PRIMARY MOTOR CORTEX #SPINAL-CORD-INJURY #HAND MOVEMENTS #MENTAL PRACTICE #FUNCTIONAL REORGANIZATION #SUBCORTICAL STROKE #HUMAN BRAIN #UPPER-LIMB #NEUROSCIENCES #NEUROIMAGING #RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING |
Tipo |
article original article publishedVersion |