Analysis of phase transition and dehydration processes of nevirapine
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
05/11/2013
05/11/2013
2012
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| Resumo |
Solid-state characterization of crystalline drugs is an important pre-formulation step for the development and design of solid dosage forms, such as pellets and tablets. In this study, phase transition and dehydration processes of nevirapine have been studied by differential scanning calorimetry and thermogravimetry differential thermal analysis to overcome the problems of drug formulation, namely poor solubility and poor content uniformity. Phase solubility studies elucidated the mechanism of enhanced nevirapine solubility. Fundacao de Amparo a Pesquisa (FAPESP) FAPESP (Fundacao de Amparo a Pesquisa) CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior) Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) |
| Identificador |
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, DORDRECHT, v. 108, n. 1, p. 53-57, APR, 2012 1388-6150 http://www.producao.usp.br/handle/BDPI/41075 10.1007/s10973-011-1424-x |
| Idioma(s) |
eng |
| Publicador |
SPRINGER DORDRECHT |
| Relação |
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY |
| Direitos |
closedAccess Copyright SPRINGER |
| Palavras-Chave | #NEVIRAPINE #DIFFERENTIAL SCANNING CALORIMETRY (DSC) #THERMOGRAVIMETRY DIFFERENTIAL THERMAL ANALYSIS (TG-DTA) #SOLID DOSAGE FORMS #SOLID-STATE FORMS #PHARMACEUTICALS #CHEMISTRY, ANALYTICAL #CHEMISTRY, PHYSICAL |
| Tipo |
article original article publishedVersion |
