Hybrid Scaffolds Built From PET and Collagen as a Model For Vascular Graft Architecture
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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| Data(s) |
04/11/2013
04/11/2013
2012
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| Resumo |
A hybrid material with excellent mechanical and biological properties is produced by electrospinning a co-solution of PET and collagen. The fibers are mapped using SEM, confocal Raman microscopy and collagenase digestion assays. Fibers of different compositions and morphologies are intermingled within the same membrane, resulting in a heterogeneous scaffold. The collagen distribution and exposure are found to depend on the PET/collagen ratio. The materials are chemically and mechanically characterized and biologically tested with fibroblasts (3T3-L1) and a HUVEC culture in vitro. All of the hybrid scaffolds show better cell attachment and proliferation than PET. These materials are potential candidates to be used as vascular grafts. CAPES Capes CNPq CNPq FAPESP Fapesp |
| Identificador |
MACROMOLECULAR BIOSCIENCE, WEINHEIM, v. 12, n. 12, p. 1660-1670, DEC, 2012 1616-5187 http://www.producao.usp.br/handle/BDPI/40870 10.1002/mabi.201200154 |
| Idioma(s) |
eng |
| Publicador |
WILEY-V C H VERLAG GMBH WEINHEIM |
| Relação |
Macromolecular Bioscience |
| Direitos |
closedAccess Copyright WILEY-V C H VERLAG GMBH |
| Palavras-Chave | #CELL PROLIFERATION #CONFOCAL RAMAN MICROSCOPY #ELECTROSPINNING #EXTRACELLULAR MATRIX PROTEINS #TISSUE ENGINEERING #SURFACE FREE-ENERGY #NANOFIBER SCAFFOLD #PROTEIN ADSORPTION #BIOMATERIALS #GROWTH #APOPTOSIS #CELLS #POLY(EPSILON-CAPROLACTONE) #DIFFERENTIATION #FIBROBLASTS #BIOCHEMISTRY & MOLECULAR BIOLOGY #MATERIALS SCIENCE, BIOMATERIALS #POLYMER SCIENCE |
| Tipo |
article original article publishedVersion |
