NADPH Oxidase and Neurodegeneration

NADPH oxidase (Nox) is a unique, multi-protein, electron transport system that produces large amounts of superoxide via the reduction of molecular oxygen. Nox-derived reactive oxygen species (ROS) are known to be involved in a variety of physiological processes, including host defense and signal transduction. However, over the past decade, the involvement of (Nox)-dependent oxidative stress in the pathophysiology of several neurodegenerative diseases has been increasingly recognized. ROS produced by Nox proteins contribute to neurodegenerative diseases through distinct mechanisms, such as oxidation of DNA, proteins, lipids, amino acids and metals, in addition to activation of redox-sensitive signaling pathways. In this review, we discuss the recent literature on Nox involvement in neurodegeneration, focusing on Parkinson and Alzheimer diseases.

Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)

FAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo)

CAPES (Coordenacao de Aperfeicoamento de Pessoal de Ensino Superior)

CAPES (Coordenacao de Aperfeicoamento de Pessoal de Ensino Superior)

University of Sao PauloNucleo de Apoio a Pesquisa em Neurociencia Aplicada

University of Sao Paulo-Nucleo de Apoio a Pesquisa em Neurociencia Aplicada

Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)

CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico)

FAPESP

FAPESP