Mitochondrial Network Size Scaling in Budding Yeast

Mitochondria must grow with the growing cell to ensure proper cellular physiology and inheritance upon division. We measured the physical size of mitochondrial networks in budding yeast and found that mitochondrial network size increased with increasing cell size and that this scaling relation occurred primarily in the bud. The mitochondria-to-cell size ratio continually decreased in aging mothers over successive generations. However, regardless of the mother's age or mitochondrial content, all buds attained the same average ratio. Thus, yeast populations achieve a stable scaling relation between mitochondrial content and cell size despite asymmetry in inheritance.

Sandler Postdoctoral Fellowship

Sandler Postdoctoral Fellowship

Herbert Boyer Junior Faculty Endowed Chair Award

Herbert Boyer Junior Faculty Endowed Chair Award

NIH

NIH [R01GM097017, R01GM070808, R01GM026259, P50Gm081879, 5RO1GM097213-02]

NIH National Research Service Award fellowship

NIH National Research Service Award fellowship

Fundacao de Amparo a Pesquisa do Estado de Sao Paulo

Fundacao de Amparo a Pesquisa do Estado de Sao Paulo [05/00587-5, 07/50882-9]

Conselho Nacional de Desenvolvimento Cientifico e Tecnologico [301303/06-1]

Conselho Nacional de Desenvolvimento Cientifico e Tecnologico

Packard Fellowship

Packard Fellowship

China Scholarship Council (CSC) scholarship

China Scholarship Council (CSC) scholarship

Boyer Postdoctoral Fellowship

Boyer Postdoctoral Fellowship