Monocyte Chemoattractant-1 as a Urinary Biomarker for the Diagnosis of Activity of Lupus Nephritis in Brazilian Patients
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
05/11/2013
05/11/2013
2012
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Resumo |
Objective. Monocyte chemotactic protein (MCP-1), involved in the pathogenesis of lupus nephritis (LN), has recently been indicated as a new biomarker of kidney activity in systemic lupus erythematosus (SLE). Our aim was to assess urinary MCP-1 (uMCP-1) as a biomarker of renal activity in patients with SLE and to compare it to other disease activity markers, using the ELISA. Methods. Seventy-five female Brazilian patients with SLE and a control group participated in our study. Patients with SLE were distributed among 3 groups according to kidney involvement and classified according to disease activity based on clinical and laboratory measures such as urinary sediment, proteinuria, kidney function, C3, C4, anti-dsDNA, disease activity index, and renal SLE disease activity index. The serum and uMCP-1 concentrations were measured by sandwich ELISA. Results. In the A-LN group (active lupus nephritis: SLE with kidney involvement), the concentration of uMCP-1 was significantly higher than in other groups. A cutoff point was established using the results of the control group to apply this test in the detection of LN. A-LN had a higher frequency of positive results for uMCP-1 in comparison to the other groups (p < 0.001). To detect disease activity in patients with LN, a new cutoff was determined based on the results of patients with SLE with kidney involvement. Setting specificity at 90%, the sensitivity of the test was 50%. Conclusion. The high specificity makes uMCP-1 a useful test as a predictor of kidney activity in SLE, especially when associated to other measures used in clinical practice. (First Release Sept 1 2012; J Rheumatol 2012;39:1948-54; doi :10.3899/jrheum.110201) |
Identificador |
JOURNAL OF RHEUMATOLOGY, TORONTO, v. 39, n. 10, pp. 1948-1954, OCT, 2012 0315-162X http://www.producao.usp.br/handle/BDPI/41544 10.3899/jrheum.110201 |
Idioma(s) |
eng |
Publicador |
J RHEUMATOL PUBL CO TORONTO |
Relação |
JOURNAL OF RHEUMATOLOGY |
Direitos |
closedAccess Copyright J RHEUMATOL PUBL CO |
Palavras-Chave | #URINARY MONOCYTE CHEMOTACTIC PROTEIN #LUPUS NEPHRITIS #RENAL ACTIVITY #ELISA #ACCURACY #ANTI-DSDNA ANTIBODIES #DISEASE-ACTIVITY #MRL/LPR MICE #ERYTHEMATOSUS #PROTEIN-1 #AUTOANTIBODIES #CLASSIFICATION #COMPLEMENT #CHEMOKINES #GENE #RHEUMATOLOGY |
Tipo |
article original article publishedVersion |