VCD to determine absolute configuration of natural product molecules: secolignans from Peperomia blanda
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
05/11/2013
05/11/2013
2012
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| Resumo |
The absolute configuration and solution-state conformers of three peperomin-type secolignans isolated from Peperomia blanda (Piperaceae) are unambiguously determined by using vibrational circular dichroism (VCD) spectroscopy associated with density functional theory (DFT) calculations. Advantages of VCD over the electronic form of CD for the analysis of diastereomers are also discussed. This work extends our growing knowledge about secondary metabolites within the Piperaceae family species while providing a definitive and straightforward method to assess the absolute stereochemistry of secolignans. State of Sao Paulo Research Foundation [FAPESP 2009/51850-9] State of Sao Paulo Research Foundation FAPESP FAPESP [2008/58658-3] CAPES CAPES Center for Scientific Computing (NCC/GridUNESP) of the Sao Paulo State University (UNESP) Center for Scientific Computing (NCC/GridUNESP) of the Sao Paulo State University (UNESP) CNPq CNPq |
| Identificador |
ORGANIC & BIOMOLECULAR CHEMISTRY, CAMBRIDGE, v. 10, n. 21, pp. 4208-4214, FEB, 2012 1477-0520 http://www.producao.usp.br/handle/BDPI/41342 10.1039/c2ob25109d |
| Idioma(s) |
eng |
| Publicador |
ROYAL SOC CHEMISTRY CAMBRIDGE |
| Relação |
ORGANIC & BIOMOLECULAR CHEMISTRY |
| Direitos |
openAccess Copyright ROYAL SOC CHEMISTRY |
| Palavras-Chave | #VIBRATIONAL CIRCULAR-DICHROISM #CHIRAL MOLECULES #TRYPANOCIDAL ACTIVITY #OBTUSIFOLIA #CHEMISTRY, ORGANIC |
| Tipo |
article original article publishedVersion |
