EVALUATION OF THE POTENTIALITIES OF A CARBON NANOTUBES/SILICONE RUBBER COMPOSITE ELECTRODE IN THE DETERMINATION OF HYDROCHLOROTHIAZIDE
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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| Data(s) |
05/11/2013
05/11/2013
2012
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| Resumo |
A multiwall carbon nanotube/silicone rubber (MWCNT/SR) composite electrode has been used for the determination of hydrochlorothiazide (HCTZ) in pharmaceutical formulations by differential pulse voltammetry (DPV). The electro-oxidation process was evaluated by cyclic voltammetry, from which it was observed that HCTZ presents an irreversible oxidation peak at 0.82 V vs. saturated calomel electrode (SCE) in the potential range from 0.5 to 1.1 V, in Britton-Robinson buffer pH 7.0 at MWCNT/SR. HCTZ was determined by DPV using a MWCNT/SR 70% (MWCNT, m/m) composite electrode after the optimization of the experimental parameters. The linear range was from 5.0 to 70.0 mu mol L-1, with a limit of detection (LOD) of 2.6 mu mol L-1. The HCTZ was determined in pharmaceutical formulations using the proposed composite electrode and the results agreed with those from the official high performance liquid chromatography (HPLC) method within 95% confidence level, according to the t-Student test. Brazilian Foundation CAPES Brazilian foundation CAPES Brazilian Foundation CNPq Brazilian Foundation CNPq Brazilian Foundation FAPESP Brazilian foundation FAPESP |
| Identificador |
ANALYTICAL LETTERS, PHILADELPHIA, v. 45, n. 11, supl. 2, Part 3, pp. 1454-1466, 43831, 2012 0003-2719 http://www.producao.usp.br/handle/BDPI/41664 10.1080/00032719.2012.675499 |
| Idioma(s) |
eng |
| Publicador |
TAYLOR & FRANCIS INC PHILADELPHIA |
| Relação |
ANALYTICAL LETTERS |
| Direitos |
restrictedAccess Copyright TAYLOR & FRANCIS INC |
| Palavras-Chave | #CARBON NANOTUBES #COMPOSITE ELECTRODES #HYDROCHLOROTHIAZIDE #SILICONE RUBBER #NANOTUBE PASTE ELECTRODES #PHARMACEUTICAL-PREPARATIONS #URINE #ELECTROANALYSIS #TABLETS #SENSOR #CHEMISTRY, ANALYTICAL |
| Tipo |
article original article publishedVersion |
