IN VITRO TRYPANOCIDAL EVALUATION OF PINANE DERIVATIVES FROM ESSENTIAL OILS OF RIPE FRUITS FROM Schinus terebinthifolius RADDI (ANACARDIACEAE)
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
04/11/2013
04/11/2013
2012
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| Resumo |
Essential oils of ripe fruits from Schinus terebinthifolius (Anacardiaceae), obtained using a pilot extractor and a Clevenger apparatus were chemically characterized. Due the high amount of (-)-alpha-pinene in both oils, this monoterpene was tested against the protozoan parasite Trypanosoma cruzi, showing a moderate potential (IC50 63.56 mu g/mL) when compared to benznidazole (IC50 43.14 mu g/mL). Otherwise, (-)-alpha-pinene oxide did not showed anti-trypanosomal activity (IC50 > 400 mu g/mL) while (-)-pinane showed an IC50 of 56.50 mu g/mL. The obtained results indicated that the epoxydation of a-pinene results to the loss of the anti-parasitic activity while its hydrogenation product, contributed slightly to the increased activity. FAPESP FAPESP CNPq CNPq |
| Identificador |
QUIMICA NOVA, SAO PAULO, v. 35, n. 4, p. 743-747, JUL, 2012 0100-4042 http://www.producao.usp.br/handle/BDPI/40831 10.1590/S0100-40422012000400017 |
| Idioma(s) |
eng |
| Publicador |
SOC BRASILEIRA QUIMICA SAO PAULO |
| Relação |
Química Nova |
| Direitos |
openAccess Copyright SOC BRASILEIRA QUIMICA |
| Palavras-Chave | #SCHINUS TEREBINTHIFOLIUS RADDI #ANACARDIACEAE #TRYPANOCIDAL ACTIVITY #CHEMICAL-COMPOSITION #LEAVES #MONOTERPENES #BERRIES #CHEMISTRY, MULTIDISCIPLINARY |
| Tipo |
article original article publishedVersion |
