Synthesis, anti-inflammatory activity and molecular docking studies of 2,5-diarylfuran amino acid derivatives
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
05/11/2013
05/11/2013
2012
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| Resumo |
A series of 2,5-diaryl substituted furans functionalized with several amino acids were synthesized and evaluated as the cyclooxygenases COX-1 and COX-2 enzymes inhibitors. The proline-substituted compound inhibited PGE(2) secretion by LPS-stimulated neutrophils, suggesting selectivity for COX-2. Molecular docking studies in the binding site of COX-2 were performed. (C) 2011 Elsevier Masson SAS. All rights reserved. FAPESP FAPESP [07/59404-2] CNPq [300613/2007, 306532/2009-3, 308116/2010-0] CNPq CAPES (Rede Nanobiotec-Brasil) [808/2009] CAPES (Rede NanobiotecBrasil) |
| Identificador |
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, PARIS, v. 47, n. 1, p. 52-58, JAN, 2012 0223-5234 http://www.producao.usp.br/handle/BDPI/41091 10.1016/j.ejmech.2011.10.018 |
| Idioma(s) |
eng |
| Publicador |
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER PARIS |
| Relação |
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY |
| Direitos |
closedAccess Copyright ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
| Palavras-Chave | #2,5-DIARYLFURAN #SUZUKI-MIYAURA #AMINO ACIDS #COX-1 AND COX-2 #DOCKING #GENETIC ALGORITHM #FURAN-DERIVATIVES #AGENTS #INHIBITION #SALTS #CYCLOOXYGENASE-2 #PROTEIN #COXIBS #COX-2 #CHEMISTRY, MEDICINAL |
| Tipo |
article original article publishedVersion |
