Differential MiRNA expression in childhood acute lymphoblastic leukemia and association with clinical and biological features
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
04/11/2013
04/11/2013
2012
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| Resumo |
The present study aimed to analyze the expression profile of the microRNAs previously described as associated with childhood ALL, miR-92a, miR-100, miR-125a-5p, miR-128a, miR-181b, miR-196b and let-7e, and their association with biological/prognostic features in 128 consecutive samples of childhood acute lymphoblastic leukemia (ALL) by quantitative real-time PCR. A significant association was observed between higher expression levels of miR-196b and T-ALL, miR-100 and patients with low white blood cell count at diagnosis and t(12;21) positive ALL. These findings suggest a potential activity of these microRNAs in pediatric ALL biology. (C) 2011 Elsevier Ltd. All rights reserved. Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2009/10191-2] Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [471129/2009-7] FAEPA (Brazil) FAEPA (Brazil) |
| Identificador |
LEUKEMIA RESEARCH, OXFORD, v. 36, n. 3, supl. 1, Part 3, pp. 293-298, MAR, 2012 0145-2126 http://www.producao.usp.br/handle/BDPI/40806 10.1016/j.leukres.2011.10.005 |
| Idioma(s) |
eng |
| Publicador |
PERGAMON-ELSEVIER SCIENCE LTD OXFORD |
| Relação |
LEUKEMIA RESEARCH |
| Direitos |
closedAccess Copyright PERGAMON-ELSEVIER SCIENCE LTD |
| Palavras-Chave | #MICRORNA #PEDIATRIC ACUTE LYMPHOBLASTIC LEUKEMIA #PROGNOSTIC FEATURES #MINIMAL-RESIDUAL-DISEASE #LUNG-CANCER CELLS #THERAPEUTIC TARGETS #MICRORNA EXPRESSION #MICROARRAY ANALYSIS #DRUG-RESISTANCE #OVARIAN-CANCER #UP-REGULATION #CARCINOMA #MIR-196B #ONCOLOGY #HEMATOLOGY |
| Tipo |
article original article publishedVersion |
