Impact of sunlight on the age of onset of bipolar disorder
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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| Data(s) |
04/11/2013
04/11/2013
2012
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| Resumo |
Bauer M, Glenn T, Alda M, Andreassen OA, Ardau R, Bellivier F, Berk M, Bjella TD, Bossini L, Del Zompo M, Dodd S, Fagiolini A, Frye MA, Gonzalez-Pinto A, Henry C, Kapczinski F, Kliwicki S, Konig B, Kunz M, Lafer B, Lopez-Jaramillo C, Manchia M, Marsh W, Martinez-Cengotitabengoa M, Melle I, Morken G, Munoz R, Nery FG, ODonovan C, Pfennig A, Quiroz D, Rasgon N, Reif A, Rybakowski J, Sagduyu K, Simhandl C, Torrent C, Vieta E, Zetin M, Whybrow PC. Impact of sunlight on the age of onset of bipolar disorder. Bipolar Disord 2012: 14: 654663. (c) 2012 The Authors. Journal compilation (c) 2012 John Wiley & Sons A/S. Objective: Although bipolar disorder has high heritability, the onset occurs during several decades of life, suggesting that social and environmental factors may have considerable influence on disease onset. This study examined the association between the age of onset and sunlight at the location of onset. Method: Data were obtained from 2414 patients with a diagnosis of bipolar I disorder, according to DSM-IV criteria. Data were collected at 24 sites in 13 countries spanning latitudes 6.3 to 63.4 degrees from the equator, including data from both hemispheres. The age of onset and location of onset were obtained retrospectively, from patient records and/or direct interviews. Solar insolation data, or the amount of electromagnetic energy striking the surface of the earth, were obtained from the NASA Surface Meteorology and Solar Energy (SSE) database for each location of onset. Results: The larger the maximum monthly increase in solar insolation at the location of onset, the younger the age of onset (coefficient= -4.724, 95% CI: -8.124 to -1.323, p = 0.006), controlling for each countrys median age. The maximum monthly increase in solar insolation occurred in springtime. No relationships were found between the age of onset and latitude, yearly total solar insolation, and the maximum monthly decrease in solar insolation. The largest maximum monthly increases in solar insolation occurred in diverse environments, including Norway, arid areas in California, and Chile. Conclusion: The large maximum monthly increase in sunlight in springtime may have an important influence on the onset of bipolar disorder. European Network of Bipolar Research Expert Centres (ENBREC) by the European Commission within the 7th Framework Programme European Network of Bipolar Research Expert Centres (ENBREC) by the European Commission within the 7th Framework Programme Canadian Institutes of Health Research [64410] Canadian Institutes of Health Research University of Oslo University of Oslo Research Council of Norway [167153/V50, 181831, 147787/320] Research Council of Norway SouthEastern Norway Health Authority South-Eastern Norway Health Authority [2010-074, 2004123, 2006258] Assistance Publique-Hopitaux de Paris [CRC 94232] Assistance PubliqueHopitaux de Paris French Ministry of Research (PHRC) French Ministry of Research (PHRC) [AOM98152] Institut National de la Sante et de la Recherche Medicale (INSERM) Institut National de la Sante et de la Recherche Medicale (INSERM) FondaMental foundation FondaMental foundation Eli Lilly Australia Eli Lilly Australia Spanish Government (CIBER Network, which is an initiative of ISCIII) [CB07/09/0024, P91A, P91E] Spanish Government (CIBER Network, which is an initiative of ISCIII) European Regional Development Funds (FEDER) European Regional Development Funds (FEDER) Kronikgune Kronikgune Stanley Research Foundation [03-RC-003] Stanley Research Foundation EU [223 102] EU CNPq CNPq CAPES CAPES Stanley Medical Research Institute Stanley Medical Research Institute NARSAD NARSAD FIPE-HCPA FIPE HCPA CAPES, Brazil CAPES (Brazil) Colciencias Colciencias CODIUdeA CODI-UdeA Sobey Fellowship Sobey Fellowship Department of Psychiatry Department of Psychiatry Dalhousie University, Halifax, NS, Canada Dalhousie University, Halifax, NS, Canada St Olavs University Hospital, Trondheim, Norway St Olavs University Hospital, Trondheim, Norway European Commission (FP7) European Commission (FP7) NIH NIH Cooperative Research Centre Cooperative Research Centre Simons Autism Foundation Simons Autism Foundation Cancer Council of Victoria Cancer Council of Victoria Stanley Medical Research Foundation Stanley Medical Research Foundation MBF MBF NHMRC NHMRC Beyond Blue Beyond Blue Geelong Medical Research Foundation Geelong Medical Research Foundation Bristol Myers Squibb BristolMyers Squibb Eli Lilly Co. Eli Lilly Co. GlaxoSmithKline GlaxoSmithKline Organon Organon Novartis Novartis Mayne Pharma Mayne Pharma Servier Servier AstraZeneca AstraZeneca Bayer Pharmaceuticals Bayer Pharmaceuticals American Diabetes Association American Diabetes Association Abbot Laboratories, Inc. Abbot Laboratories, Inc. Forest Laboratories Forest Laboratories Pfizer Inc. Pfizer, Inc. Wyeth Pharmaceuticals Wyeth Pharmaceuticals WW Norton WW Norton Sunovion Sunovion BristolMyers Squibb/Otsuka Bristol-Myers Squibb/Otsuka Pfizer Pfizer Cephalon Cephalon |
| Identificador |
BIPOLAR DISORDERS, HOBOKEN, v. 14, n. 6, supl. 1, Part 1, pp. 654-663, SEP, 2012 1398-5647 http://www.producao.usp.br/handle/BDPI/37853 10.1111/j.1399-5618.2012.01025.x |
| Idioma(s) |
eng |
| Publicador |
WILEY-BLACKWELL HOBOKEN |
| Relação |
BIPOLAR DISORDERS |
| Direitos |
closedAccess Copyright WILEY-BLACKWELL |
| Palavras-Chave | #AGE OF ONSET #BIPOLAR DISORDER #SOLAR INSOLATION #SUNLIGHT #SEASONAL AFFECTIVE-DISORDER #MANIC-DEPRESSIVE ILLNESS #VIOLENT SUICIDE #CIRCADIAN CLOCK #MOOD DISORDERS #3 SUBGROUPS #STEP-BD #LIGHT #ASSOCIATION #LATITUDE #CLINICAL NEUROLOGY #NEUROSCIENCES #PSYCHIATRY |
| Tipo |
article original article publishedVersion |
