Hematological alterations during experimental canine infection by Trypanosoma cruzi

To confirm that Beagle dogs are a good experimental model for Chagas disease, we evaluated hematological alterations during the acute and chronic phases in Beagle dogs infected with the Y, Berenice-78 (Be-78) and ABC strains of Trypanosoma cruzi, correlating clinical signs with the parasitemia curve. We demonstrate that the acute phase of infection was marked by lethargy and loss of appetite. Simultaneously, we observed anemia, leukocytosis and lymphocytosis. Also,we describe hematological alterations and clinical signs that were positively correlated with the parasitemia during the experimental infection with the three strains of T cruzi, and demonstrate that experimental infection of Beagle is a trustworthy model for Chagas disease.

Research Support Foundation of the State of Minas Gerais (FAPEMIG)

Research Support Foundation of the State of Minas Gerais (FAPEMIG)

National Research Council for Scientific and Technological Development (CNPq)

National Research Council for Scientific and Technological Development (CNPq)

Coordination Office for Advancement of Universitylevel Personnel (CAPES)

Coordination Office for Advancement of University-level Personnel (CAPES)